Putative involvement of cytokine modulation in the development of peri-operative neurocognitive disorders

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Title: Putative involvement of cytokine modulation in the development of peri-operative neurocognitive disorders
Authors: Pereira, C
Dani, M
Taylor-Robinson, S
Fertleman, M
Item Type: Journal Article
Abstract: Following surgery, local cytokine-driven inflammation occurs, as part of the normal healing process. Cytokines in the central nervous system such as IL-6 and IL-8 may also be elevated. These cytokine changes likely contribute to neuroinflammation, but the complex mechanisms through which this occurs are incompletely understood. It may be that perioperative changes in pro- and anti-inflammatory cytokines have a role in the development of perioperative neurocognitive disorders (PND), such as post-operative delirium (POD). This review considers the current evidence regarding perioperative cytokine changes in the blood and cerebrospinal fluid (CSF), as well as considering the potential for cytokine-altering therapies to prevent and treat PND.
Issue Date: 1-Jun-2022
Date of Acceptance: 23-May-2022
URI: http://hdl.handle.net/10044/1/97658
DOI: 10.2147/IJGM.S364954
ISSN: 1178-7074
Publisher: Dove Medical Press
Start Page: 5349
End Page: 5360
Journal / Book Title: International Journal of General Medicine
Volume: 15
Copyright Statement: © 2022 Pereira et al. This work is published by Dove Medical Press Limited, and licensed under a Creative Commons Attribution License. The full terms of the License are available at http://creativecommons.org/licenses/by/4.0/. The license permits unrestricted use, distribution, and reproduction in any medium, provided the original author and source are credited.
Sponsor/Funder: Wellcome Trust
Funder's Grant Number: 105603/Z/14/Z
Keywords: blood-brain barrier
central nervous system
delirium
interleukins
neuroinflammation
perioperative neurocognitive disorders
1103 Clinical Sciences
Publication Status: Published
Appears in Collections:Bioengineering



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