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Elevated 18:0 lysophosphatidylcholine contributes to the development of pain in tissue injury

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Title: Elevated 18:0 lysophosphatidylcholine contributes to the development of pain in tissue injury
Authors: Nagy, I
Friston, D
Cuddihy, J
Luiz, J
Truong, A
Laptin, H
Meirvaan, B
Peter, S
Orsolya, O
Joao, V
Tim, M
Sini, J
Helen, L
Declan, C
Marcela, V
Attila, G
Zoltan, T
Gabor, J
Elizabeth, W
Item Type: Journal Article
Abstract: Tissue injuries, including burns, are major causes of death and morbidity worldwide. These injuries result in the release of intracellular molecules and subsequent inflammatory reactions, changing the tissues’ chemical milieu and leading to the development of persistent pain through activating pain-sensing primary sensory neurons. However, the majority of pain-inducing agents in injured tissues are unknown. Here, we report that, amongst other important metabolite changes, lysophosphatidylcholines (LPCs) including 18:0 LPC exhibit significant and consistent local burn injury-induced changes in concentration. 18:0 LPC induces immediate pain and the development of hypersensitivities to mechanical and heat stimuli through molecules including the transient receptor potential ion channel, vanilloid sub-family, member 1 and member 2 at least partly via increasing lateral pressure in the membrane. As levels of LPCs including 18:0 LPC increase in other tissue injuries, our data reveal a novel role for these lipids in injury-associated pain. These findings have high potential to improve patient care.
Issue Date: 7-Jun-2022
Date of Acceptance: 27-May-2022
URI: http://hdl.handle.net/10044/1/97556
DOI: 10.1097/j.pain.0000000000002709
ISSN: 0304-3959
Publisher: Lippincott, Williams & Wilkins
Journal / Book Title: Pain
Copyright Statement: © 2022 The Author(s). This is an open access article distributed under the Creative Commons Attribution License 4.0 (CCBY), which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited
Sponsor/Funder: British Journal of Anaesthesia
NC3Rs (National Centre for the Replacement, Refinement and Reduction of Animals in Research)
Wellcome Trust
Westminster Medical School Research Trust
Westminster Medical School Research Trust
Funder's Grant Number: BJA/RCoA Grants
NC/K500409/1
102759/Z/13/Z
JRC PHD 002 03/17 - 18
JRC SG 002 2019-20
Keywords: Anesthesiology
11 Medical and Health Sciences
17 Psychology and Cognitive Sciences
Publication Status: Published online
Online Publication Date: 2022-06-07
Appears in Collections:Department of Surgery and Cancer



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