Cell competition and the regulative nature of early mammalian development

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Title: Cell competition and the regulative nature of early mammalian development
Authors: Nichols, J
Lima, A
Rodriguez, T
Item Type: Journal Article
Abstract: The mammalian embryo exhibits a remarkable plasticity that allows it to correct for the presence of aberrant cells, adjust its growth so that its size is in accordance with its developmental stage, or integrate cells of another species to form fully functional organs. Here, we will discuss the contribution that cell competition, a quality control that eliminates viable cells that are less fit than their neighbours, makes to this plasticity. We will do this by reviewing the roles that cell competition plays in the early mammalian embryo and how they contribute to ensure normal development of the embryo.
Issue Date: 7-Jul-2022
Date of Acceptance: 8-Jun-2022
URI: http://hdl.handle.net/10044/1/97496
DOI: 10.1016/j.stem.2022.06.003
ISSN: 1934-5909
Publisher: Elsevier
Start Page: 1018
End Page: 1030
Journal / Book Title: Cell Stem Cell
Volume: 29
Issue: 7
Copyright Statement: © 2022 Elsevier Inc. All rights reserved. This manuscript is licensed under the Creative Commons Attribution-NonCommercial-NoDerivatives 4.0 International Licence http://creativecommons.org/licenses/by-nc-nd/4.0/
Sponsor/Funder: Biotechnology and Biological Sciences Research Council (BBSRC)
Medical Research Council (MRC)
Medical Research Council (MRC)
Funder's Grant Number: BB/S008284/1
Keywords: Animals
Cell Competition
Embryo, Mammalian
Embryonic Development
Embryonic Development
Embryo, Mammalian
Cell Competition
Developmental Biology
06 Biological Sciences
11 Medical and Health Sciences
Publication Status: Published
Embargo Date: 2023-07-06
Online Publication Date: 2022-07-07
Appears in Collections:National Heart and Lung Institute
Faculty of Medicine

This item is licensed under a Creative Commons License Creative Commons