Acute sarcopenia after elective and emergency surgery

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Title: Acute sarcopenia after elective and emergency surgery
Authors: Shrestha, A
Dani, M
Kemp, P
Fertleman, M
Item Type: Journal Article
Abstract: Abstract Sarcopenia is an increasingly recognised condition of loss of muscle mass and function. The European Working Group on Sarcopenia in Older People 2 (EWSOP2) updated their definition in 2018, emphasising the importance of low muscle strength in diagnosis. Acute sarcopenia has been arbitrarily defined as sarcopenia lasting less than 6 months. This review highlights the pathophysiology involved in muscle wasting following surgery, focussing on hormonal factors, inflammation, microRNAs, and oxidative stress. Biomarkers such as GDF-15, IGF-1 and various microRNAs may predict post-surgical muscle loss. The impact of existing sarcopenia on various types of surgery and incident muscle wasting following surgery is also described. The gaps in research found include the need for longitudinal studies looking in changes in muscle strength and quantity following surgery. Further work is needed to examine if biomarkers are replicated in other surgery to consolidate existing theories on the pathophysiology of muscle wasting
Issue Date: 13-Apr-2022
Date of Acceptance: 4-Apr-2022
URI: http://hdl.handle.net/10044/1/97494
DOI: 10.14336/AD.2022.0404
ISSN: 2152-5250
Publisher: Buck Institute for Age Research
Journal / Book Title: Aging and Disease
Copyright Statement: © 2022 Shrestha A. et al. This is an open-access article distributed under the terms of the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original author and source are credite
Keywords: Science & Technology
Life Sciences & Biomedicine
Geriatrics & Gerontology
acute sarcopenia
muscle wasting
surgery
biomarkers
MUSCLE
Science & Technology
Life Sciences & Biomedicine
Geriatrics & Gerontology
acute sarcopenia
muscle wasting
surgery
biomarkers
MUSCLE
Publication Status: Published online
Online Publication Date: 2022-04-13
Appears in Collections:Bioengineering
Faculty of Engineering



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