SANS Study of PPPO in mixed solvents and impact on polymer nanoprecipitation

Title: SANS Study of PPPO in mixed solvents and impact on polymer nanoprecipitation
Authors: O'Connell, RA
Sharratt, WN
Aelmans, NJJ
Higgins, JS
Cabral, JT
Item Type: Journal Article
Abstract: We investigate the conformation of poly(2,6-diphenyl-p-phenylene oxide) (PPPO) in good and mixed solvents by small-angle neutron scattering (SANS) across its ternary phase diagram. Dichloromethane was selected as a “good” solvent and heptane as a “poor” solvent whose addition eventually induces demixing and polymer precipitation. Below the overlap concentration c*, the polymer conformation is found to be well described by the polymer-excluded volume model and above by the Ornstein–Zernike expression with a correlation length ξ which depends on the concentration and solvent/nonsolvent ratio. We quantify the decrease in polymer radius of gyration Rg, increase in ξ, and effective χ parameter approaching the phase boundary. Upon flash nanoprecipitation, the characteristic particle radius (estimated by scanning electron microscopy, SEM) is found to scale with polymer concentration as well as with nonsolvent content. Significantly, the solution volume per precipitated particle remains nearly constant at all polymer concentrations. Overall, our findings correlate ternary solution structure with the fabrication of polymer nanoparticles by nonsolvent-induced phase separation and precipitation.
Issue Date: 18-Jan-2022
Date of Acceptance: 1-Jan-2022
URI: http://hdl.handle.net/10044/1/97202
DOI: 10.1021/acs.macromol.1c02030
ISSN: 0024-9297
Publisher: American Chemical Society
Start Page: 1050
End Page: 1059
Journal / Book Title: Macromolecules
Volume: 55
Issue: 3
Copyright Statement: © 2022 American Chemical Society
Sponsor/Funder: Buchem BV
Royal Academy Of Engineering
Funder's Grant Number: Buchem BV PhD CDT
RCSRF1920/10/60
Keywords: Science & Technology
Physical Sciences
Polymer Science
ANGLE NEUTRON-SCATTERING
SEMI-CONCENTRATED REGION
UNPERTURBED DIMENSIONS
NANOPARTICLE FORMATION
CALCULATED SOLUBILITY
CHAIN DIMENSIONS
MACROMOLECULES
CONFORMATION
MIXTURES
BEHAVIOR
Science & Technology
Physical Sciences
Polymer Science
ANGLE NEUTRON-SCATTERING
SEMI-CONCENTRATED REGION
UNPERTURBED DIMENSIONS
NANOPARTICLE FORMATION
CALCULATED SOLUBILITY
CHAIN DIMENSIONS
MACROMOLECULES
CONFORMATION
MIXTURES
BEHAVIOR
Science & Technology
Physical Sciences
Polymer Science
ANGLE NEUTRON-SCATTERING
SEMI-CONCENTRATED REGION
UNPERTURBED DIMENSIONS
NANOPARTICLE FORMATION
CALCULATED SOLUBILITY
CHAIN DIMENSIONS
MACROMOLECULES
CONFORMATION
MIXTURES
BEHAVIOR
03 Chemical Sciences
09 Engineering
Polymers
Publication Status: Published
Open Access location: https://pubs.acs.org/doi/10.1021/acs.macromol.1c02030
Online Publication Date: 2022-01-18
Appears in Collections:Chemical Engineering
Faculty of Natural Sciences



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