2
IRUS Total
Downloads

Factors associated with infrainguinal bypass graft patency at 1-year; a retrospective analysis of a single centre experience

Title: Factors associated with infrainguinal bypass graft patency at 1-year; a retrospective analysis of a single centre experience
Authors: Normahani, P
Anwar, IY
Courtney, A
Acharya, A
Sounderajah, V
Mustafa, C
Jaffer, U
Shalhoub, J
Riga, C
Gibbs, R
Jenkins, M
Bicknell, C
Davies, AH
Nott, D
Aylwin, C
Standfield, NJ
Item Type: Journal Article
Abstract: Introduction: The aim of this study was to identify factors associated with primary graft patency 1 year following open lower limb revascularisation (LLR) at a tertiary referral vascular service. Methods: A retrospective analysis of patients undergoing infra-inguinal bypass surgery between January 2016 and May 2017 at a tertiary vascular centre (St Mary’s Hospital, London) was performed. Data regarding patient demographics, comorbidities, type of operation and post-operative anti-thrombotic strategy were collected. Quality of run-off score was assessed from pre-operative imaging. Results: Seventy-seven cases were included in the analysis. Overall, the primary patency rate at 1-year was 63.6% (n = 49/77) and the secondary patency rate was 67.5% (n = 52/77). Independent variables with statistically significant inferior patency rates at 1-year were (1) bypasses with below knee targets (p = 0.0096), (2) chronic limb threatening ischaemia indication (p = 0.038), (3) previous ipsilateral revascularisation (p < 0.001) and (4) absence of hypertension history (p = 0.041). There was also a trend towards significance for American Society of Anesthesiologists (ASA) grade (p = 0.06). Independent variables with log-rank test p values of <0.1 were included in a Cox proportional hazards model. The only variable with a statistically significant impact on primary patency rates was previous open or endovascular ipsilateral revascularisation (HR 2.44 (1.04–5.7), p = 0.04). Conclusion: At 1-year follow-up, previous ipsilateral revascularisation was the most significant factor in affecting patency rates. Patients in this subgroup should therefore be deemed high-risk, which should be reflected in the informed consent and peri-operative management.
Issue Date: 26-Feb-2021
Date of Acceptance: 1-Feb-2021
URI: http://hdl.handle.net/10044/1/96958
DOI: 10.1177/0267659121995760
ISSN: 1477-111X
Publisher: SAGE Publications
Start Page: 276
End Page: 283
Journal / Book Title: Perfusion (United Kingdom)
Volume: 37
Issue: 3
Copyright Statement: © The Author(s) 2021
Sponsor/Funder: National Institute of Health Research
Imperial College Healthcare NHS Trust- BRC Funding
Imperial College Healthcare NHS Trust- BRC Funding
Funder's Grant Number: RDB04 79560
RD207
Keywords: Science & Technology
Life Sciences & Biomedicine
Cardiac & Cardiovascular Systems
Peripheral Vascular Disease
Cardiovascular System & Cardiology
lower limb
bypass revascularization
patency
anti-thrombotic
LEG BASIL TRIAL
SEVERE ISCHEMIA
INTRAOPERATIVE DUPLEX
AMPUTATION-FREE
LIMB SALVAGE
ANGIOPLASTY
FAILURE
SURVIVAL
SURGERY
THERAPY
anti-thrombotic
bypass revascularization
lower limb
patency
Blood Vessel Prosthesis Implantation
Graft Occlusion, Vascular
Humans
Ischemia
Limb Salvage
Retrospective Studies
Risk Factors
Treatment Outcome
Vascular Patency
Collaborators
Humans
Ischemia
Graft Occlusion, Vascular
Treatment Outcome
Blood Vessel Prosthesis Implantation
Limb Salvage
Risk Factors
Retrospective Studies
Vascular Patency
Science & Technology
Life Sciences & Biomedicine
Cardiac & Cardiovascular Systems
Peripheral Vascular Disease
Cardiovascular System & Cardiology
lower limb
bypass revascularization
patency
anti-thrombotic
LEG BASIL TRIAL
SEVERE ISCHEMIA
INTRAOPERATIVE DUPLEX
AMPUTATION-FREE
LIMB SALVAGE
ANGIOPLASTY
FAILURE
SURVIVAL
SURGERY
THERAPY
1102 Cardiorespiratory Medicine and Haematology
Publication Status: Published
Article Number: ARTN 0267659121995760
Online Publication Date: 2021-02-26
Appears in Collections:Department of Immunology and Inflammation
Department of Surgery and Cancer
Institute of Global Health Innovation



This item is licensed under a Creative Commons License Creative Commons