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Epstein-Barr virus genome deletions in Epstein-Barr virus-positive T/NK cell lymphoproliferative diseases

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Title: Epstein-Barr virus genome deletions in Epstein-Barr virus-positive T/NK cell lymphoproliferative diseases
Authors: Wongwiwat, W
Fournier, B
Bassano, I
Bayoumy, A
Elgueta Karstegl, C
Styles, C
Bridges, R
Lenoir, C
BoutBoul, D
Moshous, D
Neven, B
Kanda, T
Morgan, R
White, R
Latour, S
Farrell, P
Item Type: Journal Article
Abstract: The main target cells for Epstein-Barr virus (EBV) infection and persistence are B lymphocytes, although T and NK cells can also become infected. In this paper we characterise the EBV present in 21 pediatric and adult patients treated in France for a range of diseases that involve infection of T or NK cells. Of these 21 cases, 5 pediatric patients (21%) and 11 adult patients (52%) are of Caucasian origin. In about 30% of the cases, some of the EBV genomes contain a large deletion. The deletions are different in every patient but tend to cluster near the BART region of the viral genome. Detailed investigation of a family, in which several members have persistent T or NK cell infection by EBV, indicates that the virus genome deletions arise or are selected independently in each individual patient. Genome sequence polymorphisms in the EBV in these T or NK cell diseases reflect the geographic origin of the patient, not a distinct type of EBV (the 21 cases studied included examples of both type 1 and type 2 EBV infection). Using virus produced from type 1 or type 2 EBV genomes cloned in bacterial artificial chromosome (BAC) vectors, we demonstrate infection of T cells in cord blood from healthy donors. Our results are consistent with transient infection of some T cells being part of normal asymptomatic infection by EBV in young children.
Issue Date: Jun-2022
Date of Acceptance: 3-May-2022
URI: http://hdl.handle.net/10044/1/96848
DOI: 10.1128/jvi.00394-22
ISSN: 0022-538X
Publisher: American Society for Microbiology
Start Page: 1
End Page: 15
Journal / Book Title: Journal of Virology
Volume: 96
Issue: 12
Copyright Statement: © 2022 Wongwiwat et al. This is an open-access article distributed under the terms of the Creative Commons Attribution 4.0 International license
Publication Status: Published
Online Publication Date: 2022-05-25
Appears in Collections:Department of Infectious Diseases
Faculty of Medicine

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