Trends and associated factors for Covid-19 hospitalisation and fatality risk in 2.3 million adults in England

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Title: Trends and associated factors for Covid-19 hospitalisation and fatality risk in 2.3 million adults in England
Authors: Beaney, T
Neves, AL
Alboksmaty, A
Ashrafian, H
Flott, K
Fowler, A
Benger, J
Aylin, P
Elkin, S
Darzi, A
Clarke, J
Item Type: Journal Article
Abstract: The Covid-19 mortality rate varies between countries and over time but the extent to which this is explained by the underlying risk in those infected is unclear. Using data on all adults in England with a positive Covid-19 test between 1st October 2020 and 30th April 2021 linked to clinical records, we examined trends and risk factors for hospital admission and mortality. Of 2,311,282 people included in the study, 164,046 (7.1%) were admitted and 53,156 (2.3%) died within 28 days of a positive Covid-19 test. We found significant variation in the case hospitalisation and mortality risk over time, which remained after accounting for the underlying risk of those infected. Older age groups, males, those resident in areas of greater socioeconomic deprivation, and those with obesity had higher odds of admission and death. People with severe mental illness and learning disability had the highest odds of admission and death. Our findings highlight both the role of external factors in Covid-19 admission and mortality risk and the need for more proactive care in the most vulnerable groups.
Issue Date: 29-Apr-2022
Date of Acceptance: 4-Apr-2022
DOI: 10.1038/s41467-022-29880-7
ISSN: 2041-1723
Publisher: Nature Research
Start Page: 1
End Page: 9
Journal / Book Title: Nature Communications
Volume: 13
Issue: 2356
Copyright Statement: © The Author(s) 2022. Open Access This article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons license, and indicate if changes were made. The images or other third party material in this article are included in the article’s Creative Commons license, unless indicated otherwise in a credit line to the material. If material is not included in the article’s Creative Commons license and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this license, visit
Sponsor/Funder: National Institute for Health Research
Funder's Grant Number: n/a
Keywords: Adult
Risk Factors
Publication Status: Published
Online Publication Date: 2022-04-29
Appears in Collections:Department of Surgery and Cancer
Department of Infectious Diseases
Applied Mathematics and Mathematical Physics
Faculty of Medicine
Institute of Global Health Innovation
Imperial College London COVID-19
School of Public Health
Faculty of Natural Sciences

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