Altmetric

General principles of preclinical study design.

File Description SizeFormat 
General Principles of Preclinical Study Design.pdfPublished version302.27 kBAdobe PDFView/Open
Title: General principles of preclinical study design.
Authors: Huang, W
Percie du Sert, N
Vollert, J
Rice, ASC
Item Type: Chapter
Abstract: Preclinical studies using animals to study the potential of a therapeutic drug or strategy are important steps before translation to clinical trials. However, evidence has shown that poor quality in the design and conduct of these studies has not only impeded clinical translation but also led to significant waste of valuable research resources. It is clear that experimental biases are related to the poor quality seen with preclinical studies. In this chapter, we will focus on hypothesis testing type of preclinical studies and explain general concepts and principles in relation to the design of in vivo experiments, provide definitions of experimental biases and how to avoid them, and discuss major sources contributing to experimental biases and how to mitigate these sources. We will also explore the differences between confirmatory and exploratory studies, and discuss available guidelines on preclinical studies and how to use them. This chapter, together with relevant information in other chapters in the handbook, provides a powerful tool to enhance scientific rigour for preclinical studies without restricting creativity.
Issue Date: 2020
URI: http://hdl.handle.net/10044/1/95916
DOI: 10.1007/164_2019_277
ISBN: 978-3-030-33655-4
Publisher: Springer Nature
Start Page: 55
End Page: 69
Journal / Book Title: Good reserach practice in non-clinical pharmacology and biomedicine
Handbook of experimental pharmacology
Format Info.: 21
Volume: 257
Copyright Statement: ┬ęThe Author(s) 2019
Keywords: Experimental bias
Hypothesis generating
Hypothesis testing
In vivo studies
Preclinical research
Animals
Biomedical Research
Research Design
Animals
Biomedical Research
Research Design
Experimental bias
Hypothesis generating
Hypothesis testing
In vivo studies
Preclinical research
Animals
Biomedical Research
Research Design
Notes: Published Open Access with a CC-BY licence
Place of Publication: Switzerland
Publication Status: Published
Online Publication Date: 2019-11-10
Appears in Collections:Department of Surgery and Cancer



This item is licensed under a Creative Commons License Creative Commons