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Insights into infusion-based targeted drug delivery in brain: perspectives, challenges and opportunities

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Title: Insights into infusion-based targeted drug delivery in brain: perspectives, challenges and opportunities
Authors: Jamal, A
Yuan, T
Galvan, S
Castellano, A
Riva, M
Secoli, R
Falini, A
Bello, L
Rodriguez y Baena, F
Dini, D
Item Type: Journal Article
Abstract: Targeted drug delivery in the brain is instrumental in the treatment of lethal brain diseases, such as glioblastoma multiforme, the most aggressive primary central nervous system tumour in adults. Infusion-based drug delivery techniques, which directly administer to the tissue for local treatment, as in convection-enhanced delivery (CED), provide an important opportunity; however, poor understanding of the pressure-driven drug transport mechanisms in the brain has hindered its ultimate success in clinical applications. In this review, we focus on the biomechanical and biochemical aspects of infusion-based targeted drug delivery in the brain and look into the underlying molecular level mechanisms. We discuss recent advances and challenges in the complementary field of medical robotics and its use in targeted drug delivery in the brain. A critical overview of current research in these areas and their clinical implications is provided. This review delivers new ideas and perspectives for further studies of targeted drug delivery in the brain.
Issue Date: 15-Mar-2022
Date of Acceptance: 10-Mar-2022
URI: http://hdl.handle.net/10044/1/95828
DOI: 10.3390/ijms23063139
ISSN: 1422-0067
Publisher: MDPI AG
Start Page: 3139
End Page: 3139
Journal / Book Title: International Journal of Molecular Sciences
Volume: 23
Issue: 6
Copyright Statement: © 2022 by the authors. Licensee MDPI, Basel, Switzerland. This article is an open access article distributed under the terms and conditions of the Creative Commons Attribution (CC BY) license (https://creativecommons.org/licenses/by/4.0/).
Sponsor/Funder: Engineering & Physical Science Research Council (EPSRC)
Funder's Grant Number: EP/N025954/1
Keywords: Chemical Physics
0399 Other Chemical Sciences
0604 Genetics
0699 Other Biological Sciences
Publication Status: Published
Online Publication Date: 2022-03-15
Appears in Collections:Mechanical Engineering
Institute of Global Health Innovation
Faculty of Natural Sciences

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