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Persistent COVID-19 symptoms in a community study of 606,434 people in England
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Title: | Persistent COVID-19 symptoms in a community study of 606,434 people in England |
Authors: | Whitaker, M Elliott, J Chadeau, M Riley, S Darzi, A Cooke, G Ward, H Elliott, P |
Item Type: | Journal Article |
Abstract: | Long COVID remains a broadly defined syndrome, with estimates of prevalence and duration varying widely. We use data from rounds 3–5 of the REACT-2 study (n=508,707; September 2020 – February 2021), a representative community survey of adults in England, and replication data from round 6 (n=97,717; May 2021) to estimate the prevalence and identify predictors of persistent symptoms lasting 12 weeks or more; and unsupervised learning to cluster individuals by reported symptoms. At 12 weeks in rounds 3–5, 37.7% experienced at least one symptom, falling to 21.6% in round 6. Female sex, increasing age, obesity, smoking, vaping, hospitalisation with COVID-19, deprivation, and being a healthcare worker are associated with higher probability of persistent symptoms in rounds 3–5, and Asian ethnicity with lower probability. Clustering analysis identifies a subset of participants with predominantly respiratory symptoms. Managing the long-term sequelae of COVID-19 will remain a major challenge for affected individuals and their families and for health services. |
Issue Date: | 12-Apr-2022 |
Date of Acceptance: | 16-Mar-2022 |
URI: | http://hdl.handle.net/10044/1/95785 |
DOI: | 10.1038/s41467-022-29521-z |
ISSN: | 2041-1723 |
Publisher: | Nature Research |
Journal / Book Title: | Nature Communications |
Volume: | 13 |
Issue: | 1957 |
Copyright Statement: | © The Author(s) 2022. This article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons license, and indicate if changes were made. The images or other third party material in this article are included in the article’s Creative Commons license, unless indicated otherwise in a credit line to the material. If material is not included in the article’s Creative Commons license and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this license, visit http://creativecommons.org/licenses/by/4.0/. |
Sponsor/Funder: | Imperial College Healthcare NHS Trust- BRC Funding The Huo Family Foundation UK Limited National Institute for Health Research Department of Health Cancer Research UK Commission of the European Communities National Institute for Health Research |
Funder's Grant Number: | RDF03 COVID 19 RESPONSE COV-LT-0040 n/a ‘Mechanomics’ PRC project grant 22184 874627 RP-2016-07-012 |
Keywords: | Science & Technology Multidisciplinary Sciences Science & Technology - Other Topics Adult COVID-19 England Female Humans SARS-CoV-2 |
Publication Status: | Published |
Article Number: | NCOMMS-21-26774C |
Appears in Collections: | Department of Surgery and Cancer Department of Infectious Diseases Faculty of Medicine Institute of Global Health Innovation School of Public Health |
This item is licensed under a Creative Commons License