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2021 FDA TIDES (peptides and oligonucleotides) harvest
File | Description | Size | Format | |
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pharmaceuticals-15-00222.pdf | Published version | 2.38 MB | Adobe PDF | View/Open |
Title: | 2021 FDA TIDES (peptides and oligonucleotides) harvest |
Authors: | Al Shaer, D Almusaimi, O Albericio, F De la Torre, BG |
Item Type: | Journal Article |
Abstract: | From the medical, pharmaceutical, and social perspectives, 2021 has been a year dominated by the COVID-19 pandemic. However, despite this global health crisis, the pharmaceutical industry has continued its endeavors, and 2021 could be considered an excellent year in terms of the drugs accepted by the US Food and Drug Administration (FDA). Thus, during this year, the FDA has approved 50 novel drugs, of which 36 are new chemical entities and 14 biologics. It has also authorized 10 TIDES (8 peptides, 2 oligonucleotides), in addition to 2 antibody-drug conjugates (ADCs) whose structures contain peptides. Thus, TIDES have accounted for about 24% of the approvals in the various drug categories. Importantly, this percentage has surpassed the figure in 2020 (10%), thus reflecting the remarkable success of TIDES. In this review, the approved TIDE-based drugs are analyzed on the basis of their chemical structure, medical target, mode of action, administration route, and adverse effects. |
Issue Date: | 13-Feb-2022 |
Date of Acceptance: | 11-Feb-2022 |
URI: | http://hdl.handle.net/10044/1/95772 |
DOI: | 10.3390/ph15020222 |
ISSN: | 1424-8247 |
Publisher: | MDPI AG |
Journal / Book Title: | Pharmaceuticals |
Volume: | 15 |
Issue: | 2 |
Copyright Statement: | © 2022 by the authors. Licensee MDPI, Basel, Switzerland. This article is an open access article distributed under the terms and conditions of the Creative Commons Attribution (CC BY) license (https:// creativecommons.org/licenses/by/ 4.0/). |
Keywords: | FDA Piflufolastat-F18 antibody-drug conjugate casimersen dasiglucagon difelikefalin drugs inclisiran loncastuximab tesirine-lpyl melphalan flufenamide odevixibat oligonucleotides pegcetacoplan peptides tisotumab vedotin-tftv voclosporin vosoritide 1115 Pharmacology and Pharmaceutical Sciences |
Publication Status: | Published |
Article Number: | ARTN 222 |
Appears in Collections: | Chemical Engineering |
This item is licensed under a Creative Commons License