A prenylated dsRNA sensor protects against severe COVID-19

Title:	A prenylated dsRNA sensor protects against severe COVID-19
Authors:	Wickenhagen, A Sugrue, E Lytras, S Kuchi, S Noerenberg, M Turnbull, ML Loney, C Herder, V Allan, J Jarmson, I Cameron-Ruiz, N Varjak, M Pinto, RM Lee, JY Iselin, L Palmalux, N Stewart, DG Swingler, S Greenwood, EJD Crozier, TWM Gu, Q Davies, EL Clohisey, S Wang, B Maranhao Costa, FT Santana, MF De Lima Ferreira, LC Murphy, L Fawkes, A Meynert, A Grimes, G Filho, JLDS Marti, M Hughes, J Stanton, RJ Wang, ECY Ho, A Davis, I Jarrett, RF Castello, A Robertson, DL Semple, MG Openshaw, PJM Palmarini, M Lehner, PJ Baillie, JK Rihn, SJ Wilson, SJ
Item Type:	Journal Article
Issue Date:	29-Oct-2021
Date of Acceptance:	23-Sep-2021
URI:	http://hdl.handle.net/10044/1/95147
DOI:	10.1126/science.abj3624
ISSN:	0036-8075
Publisher:	Amer Assoc Advancement Science
Start Page:	1
End Page:	18
Journal / Book Title:	Science
Volume:	374
Issue:	6567
Copyright Statement:	© 2021 The Authors, some rights reserved; exclusive licensee American Association for the Advancement of Science. No claim to original U.S. Government Works. Distributed under a Creative Commons Attribution License 4.0 (CC BY). This is an open-access article distributed under the terms of the Creative Commons Attribution license, which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited. https://creativecommons.org/licenses/by/4.0/
Sponsor/Funder:	National Institute for Health Research UK Research and Innovation UKRI MRC COVID-19 Rapid Response Call
Funder's Grant Number:	RP-2016-07-012 9815274 MC_PC_19025 MC_PC19025
Keywords:	Science & Technology Multidisciplinary Sciences Science & Technology - Other Topics SINGLE-NUCLEOTIDE POLYMORPHISM SPLICE-SITE POLYMORPHISM VIRUS NS1 PROTEIN RNASE-L CORONAVIRUS REPLICATION SARS-CORONAVIRUS ENZYME-ACTIVITY ACCEPTOR SITE I INTERFERON L PATHWAY 2',5'-Oligoadenylate Synthetase 5' Untranslated Regions A549 Cells Animals COVID-19 Chiroptera Coronaviridae Endoribonucleases Humans Interferons Isoenzymes Phosphoric Diester Hydrolases Polymorphism, Single Nucleotide Protein Prenylation RNA, Double-Stranded RNA, Viral Retroelements SARS-CoV-2 Severity of Illness Index Virus Replication ISARIC4C Investigators Animals Chiroptera Humans Coronaviridae Endoribonucleases Phosphoric Diester Hydrolases Isoenzymes 2',5'-Oligoadenylate Synthetase Interferons Retroelements RNA, Double-Stranded 5' Untranslated Regions RNA, Viral Severity of Illness Index Virus Replication Polymorphism, Single Nucleotide Protein Prenylation A549 Cells COVID-19 SARS-CoV-2 Science & Technology Multidisciplinary Sciences Science & Technology - Other Topics SINGLE-NUCLEOTIDE POLYMORPHISM SPLICE-SITE POLYMORPHISM VIRUS NS1 PROTEIN RNASE-L CORONAVIRUS REPLICATION SARS-CORONAVIRUS ENZYME-ACTIVITY ACCEPTOR SITE I INTERFERON L PATHWAY General Science & Technology
Publication Status:	Published
Open Access location:	https://www.science.org/doi/10.1126/science.abj3624
Article Number:	ARTN 579
Online Publication Date:	2021-09-28
Appears in Collections:	Department of Metabolism, Digestion and Reproduction Department of Surgery and Cancer Department of Infectious Diseases National Heart and Lung Institute Imperial College London COVID-19

This item is licensed under a Creative Commons License