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A prenylated dsRNA sensor protects against severe COVID-19

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Title: A prenylated dsRNA sensor protects against severe COVID-19
Authors: Wickenhagen, A
Sugrue, E
Lytras, S
Kuchi, S
Noerenberg, M
Turnbull, ML
Loney, C
Herder, V
Allan, J
Jarmson, I
Cameron-Ruiz, N
Varjak, M
Pinto, RM
Lee, JY
Iselin, L
Palmalux, N
Stewart, DG
Swingler, S
Greenwood, EJD
Crozier, TWM
Gu, Q
Davies, EL
Clohisey, S
Wang, B
Maranhao Costa, FT
Santana, MF
De Lima Ferreira, LC
Murphy, L
Fawkes, A
Meynert, A
Grimes, G
Filho, JLDS
Marti, M
Hughes, J
Stanton, RJ
Wang, ECY
Ho, A
Davis, I
Jarrett, RF
Castello, A
Robertson, DL
Semple, MG
Openshaw, PJM
Palmarini, M
Lehner, PJ
Baillie, JK
Rihn, SJ
Wilson, SJ
Item Type: Journal Article
Issue Date: 29-Oct-2021
Date of Acceptance: 23-Sep-2021
URI: http://hdl.handle.net/10044/1/95147
DOI: 10.1126/science.abj3624
ISSN: 0036-8075
Publisher: Amer Assoc Advancement Science
Start Page: 1
End Page: 18
Journal / Book Title: Science
Volume: 374
Issue: 6567
Copyright Statement: © 2021 The Authors, some rights reserved; exclusive licensee American Association for the Advancement of Science. No claim to original U.S. Government Works. Distributed under a Creative Commons Attribution License 4.0 (CC BY). This is an open-access article distributed under the terms of the Creative Commons Attribution license, which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited. https://creativecommons.org/licenses/by/4.0/
Sponsor/Funder: National Institute for Health Research
UK Research and Innovation
UKRI MRC COVID-19 Rapid Response Call
Funder's Grant Number: RP-2016-07-012
9815274 MC_PC_19025
MC_PC19025
Keywords: Science & Technology
Multidisciplinary Sciences
Science & Technology - Other Topics
SINGLE-NUCLEOTIDE POLYMORPHISM
SPLICE-SITE POLYMORPHISM
VIRUS NS1 PROTEIN
RNASE-L
CORONAVIRUS REPLICATION
SARS-CORONAVIRUS
ENZYME-ACTIVITY
ACCEPTOR SITE
I INTERFERON
L PATHWAY
2',5'-Oligoadenylate Synthetase
5' Untranslated Regions
A549 Cells
Animals
COVID-19
Chiroptera
Coronaviridae
Endoribonucleases
Humans
Interferons
Isoenzymes
Phosphoric Diester Hydrolases
Polymorphism, Single Nucleotide
Protein Prenylation
RNA, Double-Stranded
RNA, Viral
Retroelements
SARS-CoV-2
Severity of Illness Index
Virus Replication
ISARIC4C Investigators
Animals
Chiroptera
Humans
Coronaviridae
Endoribonucleases
Phosphoric Diester Hydrolases
Isoenzymes
2',5'-Oligoadenylate Synthetase
Interferons
Retroelements
RNA, Double-Stranded
5' Untranslated Regions
RNA, Viral
Severity of Illness Index
Virus Replication
Polymorphism, Single Nucleotide
Protein Prenylation
A549 Cells
COVID-19
SARS-CoV-2
Science & Technology
Multidisciplinary Sciences
Science & Technology - Other Topics
SINGLE-NUCLEOTIDE POLYMORPHISM
SPLICE-SITE POLYMORPHISM
VIRUS NS1 PROTEIN
RNASE-L
CORONAVIRUS REPLICATION
SARS-CORONAVIRUS
ENZYME-ACTIVITY
ACCEPTOR SITE
I INTERFERON
L PATHWAY
General Science & Technology
Publication Status: Published
Open Access location: https://www.science.org/doi/10.1126/science.abj3624
Article Number: ARTN 579
Online Publication Date: 2021-09-28
Appears in Collections:Department of Metabolism, Digestion and Reproduction
Department of Surgery and Cancer
Department of Infectious Diseases
National Heart and Lung Institute
Imperial College London COVID-19



This item is licensed under a Creative Commons License Creative Commons