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Bone phenotyping approaches in human, mice and zebrafish - expert overview of the EU cost action GEMSTONE ("GEnomics of MusculoSkeletal traits TranslatiOnal NEtwork")

Title: Bone phenotyping approaches in human, mice and zebrafish - expert overview of the EU cost action GEMSTONE ("GEnomics of MusculoSkeletal traits TranslatiOnal NEtwork")
Authors: Foessl, I
Bassett, JHD
Bjornerem, A
Busse, B
Calado, A
Chavassieux, P
Christou, M
Douni, E
Fiedler, IAK
Fonseca, JE
Hassler, E
Hoegler, W
Kague, E
Karasik, D
Khashayar, P
Langdahl, BL
Leitch, VD
Lopes, P
Markozannes, G
McGuigan, FEA
Medina-Gomez, C
Ntzani, E
Oei, L
Ohlsson, C
Szulc, P
Tobias, JH
Trajanoska, K
Tuzun, S
Valjevac, A
Van Rietbergen, B
Williams, GR
Zekic, T
Rivadeneira, F
Obermayer-Pietsch, B
Item Type: Journal Article
Abstract: A synoptic overview of scientific methods applied in bone and associated research fields across species has yet to be published. Experts from the EU Cost Action GEMSTONE (“GEnomics of MusculoSkeletal Traits translational Network”) Working Group 2 present an overview of the routine techniques as well as clinical and research approaches employed to characterize bone phenotypes in humans and selected animal models (mice and zebrafish) of health and disease. The goal is consolidation of knowledge and a map for future research. This expert paper provides a comprehensive overview of state-of-the-art technologies to investigate bone properties in humans and animals – including their strengths and weaknesses. New research methodologies are outlined and future strategies are discussed to combine phenotypic with rapidly developing –omics data in order to advance musculoskeletal research and move towards “personalised medicine”.
Issue Date: 1-Dec-2021
Date of Acceptance: 21-Oct-2021
URI: http://hdl.handle.net/10044/1/94835
DOI: 10.3389/fendo.2021.720728
ISSN: 1664-2392
Publisher: Frontiers Media
Start Page: 1
End Page: 32
Journal / Book Title: Frontiers in Endocrinology
Volume: 12
Copyright Statement: © 2021 Foessl, Bassett, Bjørnerem, Busse, Calado, Chavassieux, Christou, Douni, Fiedler, Fonseca, Hassler, Högler, Kague, Karasik, Khashayar, Langdahl, Leitch, Lopes, Markozannes, McGuigan, Medina-Gomez, Ntzani, Oei, Ohlsson, Szulc, Tobias, Trajanoska, Tuzun, Valjevac, van Rietbergen, Williams, Zekic, Rivadeneira and Obermayer-Pietsch. This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) and the copyright owner(s) are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms.
Sponsor/Funder: Wellcome Trust
Wellcome Trust
Funder's Grant Number: 101123/Z/13/A
110141/Z/15/Z
Keywords: Science & Technology
Life Sciences & Biomedicine
Endocrinology & Metabolism
bone and skeletal diseases
phenotyping
imaging
animal models
GEMSTONE
COST
QUANTITATIVE COMPUTED-TOMOGRAPHY
REFERENCE POINT INDENTATION
MINERALIZATION DENSITY DISTRIBUTION
VERTEBRAL FRACTURE ASSESSMENT
BRANCHIAL ARCH MUTANTS
X-RAY ABSORPTIOMETRY
IN-VIVO ASSESSMENT
MECHANICAL-PROPERTIES
TURNOVER MARKERS
HIP FRACTURE
COST
GEMSTONE
animal models
bone and skeletal diseases
imaging
phenotyping
Science & Technology
Life Sciences & Biomedicine
Endocrinology & Metabolism
bone and skeletal diseases
phenotyping
imaging
animal models
GEMSTONE
COST
QUANTITATIVE COMPUTED-TOMOGRAPHY
REFERENCE POINT INDENTATION
MINERALIZATION DENSITY DISTRIBUTION
VERTEBRAL FRACTURE ASSESSMENT
BRANCHIAL ARCH MUTANTS
X-RAY ABSORPTIOMETRY
IN-VIVO ASSESSMENT
MECHANICAL-PROPERTIES
TURNOVER MARKERS
HIP FRACTURE
1103 Clinical Sciences
1111 Nutrition and Dietetics
Publication Status: Published
Article Number: ARTN 720728
Online Publication Date: 2021-12-01
Appears in Collections:Department of Metabolism, Digestion and Reproduction
School of Public Health



This item is licensed under a Creative Commons License Creative Commons