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Rapid increase in Omicron infections in England during December 2021: REACT-1 study.

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Title: Rapid increase in Omicron infections in England during December 2021: REACT-1 study.
Authors: Elliott, P
Bodinier, B
Eales, O
Wang, H
Haw, D
Elliott, J
Whitaker, M
Jonnerby, J
Tang, D
Walters, CE
Atchison, C
Diggle, PJ
Page, AJ
Trotter, AJ
Ashby, D
Barclay, W
Taylor, G
Ward, H
Darzi, A
Cooke, GS
Chadeau-Hyam, M
Donnelly, CA
Item Type: Journal Article
Abstract: The unprecedented rise in SARS-CoV-2 infections during December 2021 was concurrent with rapid spread of the Omicron variant in England and globally. We analyzed prevalence of SARS-CoV-2 and its dynamics in England from end November to mid-December 2021 among almost 100,000 participants from the REACT-1 study. Prevalence was high with rapid growth nationally and particularly in London during December 2021, and an increasing proportion of infections due to Omicron. We observed large falls in swab positivity among mostly vaccinated older children (12-17 years) compared with unvaccinated younger children (5-11 years), and in adults who received a third (booster) vaccine dose vs. two doses. Our results reinforce the importance of vaccination and booster campaigns, although additional measures have been needed to control the rapid growth of the Omicron variant.
Issue Date: 8-Feb-2022
Date of Acceptance: 1-Feb-2022
URI: http://hdl.handle.net/10044/1/94586
DOI: 10.1126/science.abn8347
ISSN: 0036-8075
Publisher: AAAS
Start Page: eabn8347
End Page: eabn8347
Journal / Book Title: Science
Volume: 375
Issue: 6587
Copyright Statement: © 2022 The Author(s). This work is licensed under a Creative Commons Attribution 4.0 International (CC BY 4.0) license, which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited. To view a copy of this license, visit https://creativecommons.org/licenses/by/4.0/. This license does not apply to figures/photos/artwork or other content included in the article that is credited to a third party; obtain authorization from the rights holder before using such material.
Sponsor/Funder: Cancer Research UK
Commission of the European Communities
Health Data Research Uk
Department of Health
Imperial College Healthcare NHS Trust- BRC Funding
Medical Research Council (MRC)
Funder's Grant Number: ‘Mechanomics’ PRC project grant 22184
Health Data Research UK
Keywords: General Science & Technology
Publication Status: Published online
Conference Place: United States
Online Publication Date: 2022-02-08
Appears in Collections:Department of Surgery and Cancer
Department of Infectious Diseases
Faculty of Medicine
Institute of Global Health Innovation
School of Public Health

This item is licensed under a Creative Commons License Creative Commons