A neuropeptidergic circuit gates selective escape behavior of Drosophila larvae

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Title: A neuropeptidergic circuit gates selective escape behavior of Drosophila larvae
Authors: Imambocus, BN
Zhou, F
Formozov, A
Wittich, A
Tenedini, FM
Hu, C
Sauter, K
Macarenhas Varela, E
Herédia, F
Casimiro, AP
Macedo, A
Schlegel, P
Yang, C-H
Miguel-Aliaga, I
Wiegert, JS
Pankratz, MJ
Gontijo, AM
Cardona, A
Soba, P
Item Type: Journal Article
Abstract: Animals display selective escape behaviors when faced with environmental threats. Selection of the appropriate response by the underlying neuronal network is key to maximizing chances of survival, yet the underlying network mechanisms are so far not fully understood. Using synapse-level reconstruction of the Drosophila larval network paired with physiological and behavioral readouts, we uncovered a circuit that gates selective escape behavior for noxious light through acute and input-specific neuropeptide action. Sensory neurons required for avoidance of noxious light and escape in response to harsh touch, each converge on discrete domains of neuromodulatory hub neurons. We show that acute release of hub neuron-derived insulin-like peptide 7 (Ilp7) and cognate relaxin family receptor (Lgr4) signaling in downstream neurons are required for noxious light avoidance, but not harsh touch responses. Our work highlights a role for compartmentalized circuit organization and neuropeptide release from regulatory hubs, acting as central circuit elements gating escape responses.
Issue Date: 10-Jan-2022
Date of Acceptance: 29-Oct-2021
URI: http://hdl.handle.net/10044/1/94232
DOI: 10.1016/j.cub.2021.10.069
ISSN: 0960-9822
Publisher: Elsevier
Start Page: 149
End Page: 163.e8
Journal / Book Title: Current Biology
Volume: 32
Issue: 1
Copyright Statement: © 2021 Elsevier Inc. All rights reserved. This manuscript is licensed under the Creative Commons Attribution-NonCommercial-NoDerivatives 4.0 International Licence http://creativecommons.org/licenses/by-nc-nd/4.0/
Keywords: Drosophila melanogaster
GPCR
connectomics
escape behavior
light avoidance
neuromodulation
neuropeptide
nociception
noxious light
sensory gating
Drosophila melanogaster
GPCR
connectomics
escape behavior
light avoidance
neuromodulation
neuropeptide
nociception
noxious light
sensory gating
Developmental Biology
06 Biological Sciences
11 Medical and Health Sciences
17 Psychology and Cognitive Sciences
Publication Status: Published
Conference Place: England
Embargo Date: 2022-11-17
Online Publication Date: 2021-11-18
Appears in Collections:Institute of Clinical Sciences



This item is licensed under a Creative Commons License Creative Commons