Metabolic decisions in development and disease-a Keystone Symposia report

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Title: Metabolic decisions in development and disease-a Keystone Symposia report
Authors: Cable, J
Pourquie, O
Wellen, KE
Finley, LWS
Aulehla, A
Gould, AP
Teleman, A
Tu, WB
Garrett, WS
Miguel-Aliaga, I
Perrimon, N
Hooper, LV
Walhout, AJM
Wei, W
Alexandrov, T
Erez, A
Ralser, M
Rabinowitz, JD
Hemalatha, A
Gutierrez-Perez, P
Chandel, NS
Rutter, J
Locasale, JW
Landoni, JC
Christofk, H
Item Type: Journal Article
Abstract: There is an increasing appreciation for the role of metabolism in cell signaling and cell decision making. Precise metabolic control is essential in development, as evident by the disorders caused by mutations in metabolic enzymes. The metabolic profile of cells is often cell-type specific, changing as cells differentiate or during tumorigenesis. Recent evidence has shown that changes in metabolism are not merely a consequence of changes in cell state but that metabolites can serve to promote and/or inhibit these changes. Metabolites can link metabolic pathways with cell signaling pathways via several mechanisms, for example, by serving as substrates for protein post-translational modifications, by affecting enzyme activity via allosteric mechanisms, or by altering epigenetic markers. Unraveling the complex interactions governing metabolism, gene expression, and protein activity that ultimately govern a cell's fate will require new tools and interactions across disciplines. On March 24 and 25, 2021, experts in cell metabolism, developmental biology, and human disease met virtually for the Keystone eSymposium, “Metabolic Decisions in Development and Disease.” The discussions explored how metabolites impact cellular and developmental decisions in a diverse range of model systems used to investigate normal development, developmental disorders, dietary effects, and cancer-mediated changes in metabolism.
Issue Date: Dec-2021
Date of Acceptance: 31-Jul-2021
URI: http://hdl.handle.net/10044/1/94220
DOI: 10.1111/nyas.14678
ISSN: 0077-8923
Publisher: Wiley
Start Page: 55
End Page: 73
Journal / Book Title: Annals of the New York Academy of Sciences
Volume: 1506
Issue: 1
Copyright Statement: © 2021 New York Academy of Sciences. This is the accepted version of the following article: Cable, J., Pourquié, O., Wellen, K.E., Finley, L.W.S., Aulehla, A., Gould, A.P., Teleman, A., Tu, W.B., Garrett, W.S., Miguel-Aliaga, I., Perrimon, N., Hooper, L.V., Walhout, A.J.M., Wei, W., Alexandrov, T., Erez, A., Ralser, M., Rabinowitz, J.D., Hemalatha, A., Gutiérrez-Pérez, P., Chandel, N.S., Rutter, J., Locasale, J.W., Landoni, J.C. and Christofk, H. (2021), Metabolic decisions in development and disease—a Keystone Symposia report. Ann. N.Y. Acad. Sci., 1506: 55-73, which has been published in final form at https://doi.org/10.1111/nyas.14678
Keywords: Science & Technology
Multidisciplinary Sciences
Science & Technology - Other Topics
cell signaling
development
inborn errors of metabolism
metabolism
metabolome
stem cell differentiation
MITOCHONDRIAL PYRUVATE CARRIER
STEM-CELL FUNCTION
GROWTH
TISSUE
DROSOPHILA
YEAST
DIFFERENTIATION
IDENTIFICATION
EXPRESSION
MAINTAINS
cell signaling
development
inborn errors of metabolism
metabolism
metabolome
stem cell differentiation
Science & Technology
Multidisciplinary Sciences
Science & Technology - Other Topics
cell signaling
development
inborn errors of metabolism
metabolism
metabolome
stem cell differentiation
MITOCHONDRIAL PYRUVATE CARRIER
STEM-CELL FUNCTION
GROWTH
TISSUE
DROSOPHILA
YEAST
DIFFERENTIATION
IDENTIFICATION
EXPRESSION
MAINTAINS
General Science & Technology
Publication Status: Published
Embargo Date: 2022-08-18
Online Publication Date: 2021-08-19
Appears in Collections:Institute of Clinical Sciences