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Comparative efficacy of two pyrethroid-piperonyl butoxide nets (Olyset Plus and PermaNet 3.0) against pyrethroid resistant malaria vectors: a non-inferiority assessment

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Title: Comparative efficacy of two pyrethroid-piperonyl butoxide nets (Olyset Plus and PermaNet 3.0) against pyrethroid resistant malaria vectors: a non-inferiority assessment
Authors: Ngufor, C
Fagbohoun, J
Agbevo, A
Ismail, H
Challenger, JD
Churcher, TS
Rowland, M
Item Type: Journal Article
Abstract: Background Pyrethroid-PBO nets were conditionally recommended for control of malaria transmitted by mosquitoes with oxidase-based pyrethroid-resistance based on epidemiological evidence of additional protective effect with Olyset Plus compared to a pyrethroid-only net (Olyset Net). Entomological studies can be used to assess the comparative performance of other brands of pyrethroid-PBO ITNs to Olyset Plus. Methods An experimental hut trial was performed in Cové, Benin to compare PermaNet 3.0 (deltamethrin plus PBO on roof panel only) to Olyset Plus (permethrin plus PBO on all panels) against wild pyrethroid-resistant Anopheles gambiae sensu lato (s.l.) following World Health Organization (WHO) guidelines. Both nets were tested unwashed and after 20 standardized washes compared to Olyset Net. Laboratory bioassays were also performed to help explain findings in the experimental huts. Results With unwashed nets, mosquito mortality was higher in huts with PermaNet 3.0 compared to Olyset Plus (41% vs. 28%, P < 0.001). After 20 washes, mortality declined significantly with PermaNet 3.0 (41% unwashed vs. 17% after washing P < 0.001), but not with Olyset Plus (28% unwashed vs. 24% after washing P = 0.433); Olyset Plus induced significantly higher mortality than PermaNet 3.0 and Olyset Net after 20 washes. PermaNet 3.0 showed a higher wash retention of PBO compared to Olyset Plus. A non-inferiority analysis performed with data from unwashed and washed nets together using a margin recommended by the WHO, showed that PermaNet 3.0 was non-inferior to Olyset Plus in terms of mosquito mortality (25% with Olyset Plus vs. 27% with PermaNet 3.0, OR = 1.528, 95%CI = 1.02–2.29) but not in reducing mosquito feeding (25% with Olyset Plus vs. 30% with PermaNet 3.0, OR = 1.192, 95%CI = 0.77–1.84). Both pyrethroid-PBO nets were superior to Olyset Net. Conclusion Olyset Plus outperformed PermaNet 3.0 in terms of its ability to cause greater margins of improved mosquito mortality compared to a standard pyrethroid net, after multiple standardized washes. However, using a margin of non-inferiority defined by the WHO, PermaNet 3.0 was non-inferior to Olyset Plus in inducing mosquito mortality. Considering the low levels of mortality observed and increasing pyrethroid-resistance in West Africa, it is unclear whether either of these nets would demonstrate the same epidemiological impact observed in community trials in East Africa.
Issue Date: 11-Jan-2022
Date of Acceptance: 3-Jan-2022
URI: http://hdl.handle.net/10044/1/94160
DOI: 10.1186/s12936-022-04041-9
ISSN: 1475-2875
Publisher: BioMed Central
Start Page: 1
End Page: 13
Journal / Book Title: Malaria Journal
Volume: 21
Issue: 1
Copyright Statement: © The Author(s) 2022. Open Access This article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons licence, and indicate if changes were made. The images or other third party material in this article are included in the article’s Creative Commons licence, unless indicated otherwise in a credit line to the material. If material is not included in the article’s Creative Commons licence and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this licence, visit http://creativecommons.org/licenses/by/4.0/. The Creative Commons Public Domain Dedication waiver (http://creativeco mmons.org/publicdomain/zero/1.0/) applies to the data made available in this article, unless otherwise stated in a credit line to the data.
Sponsor/Funder: Bill & Melinda Gates Foundation
Funder's Grant Number: n/a
Keywords: Science & Technology
Life Sciences & Biomedicine
Infectious Diseases
Parasitology
Tropical Medicine
Experimental huts
Piperonyl butoxide
PBO
Olyset plus
PermaNet 3
0
Olyset
Mixture
LLIN
Insecticide resistance
Pyrethroid-PBO
Cove
Benin
Pyrethroid resistance
Insecticide-treated nets
Long-lasting insecticidal nets
Next generation nets
Anopheles
Cove Benin
MOSQUITOS
Anopheles
Benin
Cove
Cove Benin
Experimental huts
Insecticide resistance
Insecticide-treated nets
LLIN
Long-lasting insecticidal nets
Mixture
Next generation nets
Olyset
Olyset plus
PBO
PermaNet 3.0
Piperonyl butoxide
Pyrethroid resistance
Pyrethroid-PBO
Animals
Anopheles
Benin
Insecticide Resistance
Insecticide-Treated Bednets
Malaria
Mosquito Control
Mosquito Vectors
Piperonyl Butoxide
Pyrethrins
Animals
Anopheles
Malaria
Pyrethrins
Piperonyl Butoxide
Mosquito Control
Insecticide Resistance
Benin
Insecticide-Treated Bednets
Mosquito Vectors
Science & Technology
Life Sciences & Biomedicine
Infectious Diseases
Parasitology
Tropical Medicine
Experimental huts
Piperonyl butoxide
PBO
Olyset plus
PermaNet 3
0
Olyset
Mixture
LLIN
Insecticide resistance
Pyrethroid-PBO
Cove
Benin
Pyrethroid resistance
Insecticide-treated nets
Long-lasting insecticidal nets
Next generation nets
Anopheles
Cove Benin
MOSQUITOS
Tropical Medicine
0605 Microbiology
1108 Medical Microbiology
1117 Public Health and Health Services
Publication Status: Published
Open Access location: https://doi.org/10.1186/s12936-022-04041-9
Article Number: ARTN 20
Online Publication Date: 2022-01-11
Appears in Collections:School of Public Health



This item is licensed under a Creative Commons License Creative Commons