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Immuno-proteomic profiling reveals aberrant immune cell regulation in the airways of individuals with ongoing post-COVD-19 respiratory disease

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Title: Immuno-proteomic profiling reveals aberrant immune cell regulation in the airways of individuals with ongoing post-COVD-19 respiratory disease
Authors: Vijayakumar, B
Boustani, K
Ogger, P
Papadaki, A
Tonkin, J
Orton, C
Ghai, P
Suveizdyte, K
Hewitt, R
Desai, S
Devaraj, A
Snelgrove, R
Molyneaux, P
Garner, J
Peters, J
Shah, P
Lloyd, C
Harker, J
Item Type: Journal Article
Abstract: Some patients hospitalized with acute COVID-19 suffer respiratory symptoms that persist for many months. We delineated the immune-proteomic landscape in the airway and peripheral blood of healthy controls and post-COVID-19 patients 3 to 6 months after hospital discharge. Post-COVID-19 patients showed abnormal airway (but not plasma) proteomes, with elevated concentration of proteins associated with apoptosis, tissue repair and epithelial injury versus healthy individuals. Increased numbers of cytotoxic lymphocytes were observed in individuals with greater airway dysfunction, while increased B cell numbers and altered monocyte subsets were associated with more widespread lung abnormalities. 1 year follow-up of some post-COVID-19 patients indicated that these abnormalities resolved over time. In summary, COVID-19 causes a prolonged change to the airway immune landscape in those with persistent lung disease, with evidence of cell death and tissue repair linked to ongoing activation of cytotoxic T cells.
Issue Date: 1-Mar-2022
Date of Acceptance: 21-Jan-2022
URI: http://hdl.handle.net/10044/1/94155
DOI: 10.1016/j.immuni.2022.01.017
ISSN: 1074-7613
Publisher: Elsevier
Start Page: 542
End Page: 556.e5
Journal / Book Title: Immunity
Volume: 55
Issue: 3
Copyright Statement: © 2022 The Authors. Published by Elsevier Inc. This is an open access article under the CC BY license (http://creativecommons.org/licenses/by/4.0/
Sponsor/Funder: Asthma UK
Rosetrees Trust
Action for Pulmonary Fibrosis
Medical Research Council (MRC)
Wellcome Trust
Funder's Grant Number: Asthma UK Centre
A2172
n/a
MR/W006111/1
087618/Z/08/Z
Keywords: COVID-19
SARS-CoV-2
T cells
airways
long COVID
proteomics
respiratory tract
respiratory viral infection
tissue-resident memory
Adult
Aged
B-Lymphocytes
COVID-19
Female
Follow-Up Studies
Humans
Immunity, Cellular
Immunoproteins
Male
Middle Aged
Monocytes
Proteome
Respiration Disorders
Respiratory System
SARS-CoV-2
T-Lymphocytes, Cytotoxic
Respiratory System
B-Lymphocytes
T-Lymphocytes, Cytotoxic
Monocytes
Humans
Respiration Disorders
Immunoproteins
Proteome
Follow-Up Studies
Immunity, Cellular
Adult
Aged
Middle Aged
Female
Male
COVID-19
SARS-CoV-2
Immunology
1107 Immunology
Publication Status: Published
Online Publication Date: 2022-01-26
Appears in Collections:Department of Immunology and Inflammation
National Heart and Lung Institute
Faculty of Medicine



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