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Urinary metabolic biomarkers of diet quality in European children are associated with metabolic health

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Title: Urinary metabolic biomarkers of diet quality in European children are associated with metabolic health
Authors: Stratakis, N
Siskos, AP
Papadopoulou, E
Nguyen, AN
Zhao, Y
Margetaki, K
Lau, C-HE
Coen, M
Maitre, L
Fernández-Barrés, S
Agier, L
Andrusaityte, S
Basagaña, X
Brantsaeter, AL
Casas, M
Fossati, S
Grazuleviciene, R
Heude, B
McEachan, RRC
Meltzer, HM
Millett, C
Rauber, F
Robinson, O
Roumeliotaki, T
Borras, E
Sabidó, E
Urquiza, J
Vafeiadi, M
Vineis, P
Voortman, T
Wright, J
Conti, DV
Vrijheid, M
Keun, HC
Chatzi, L
Item Type: Journal Article
Abstract: Urinary metabolic profiling is a promising powerful tool to reflect dietary intake and can help understand metabolic alterations in response to diet quality. Here, we used 1H NMR spectroscopy in a multicountry study in European children (1147 children from 6 different cohorts) and identified a common panel of 4 urinary metabolites (hippurate, N-methylnicotinic acid, urea, and sucrose) that was predictive of Mediterranean diet adherence (KIDMED) and ultra-processed food consumption and also had higher capacity in discriminating children’s diet quality than that of established sociodemographic determinants. Further, we showed that the identified metabolite panel also reflected the associations of these diet quality indicators with C-peptide, a stable and accurate marker of insulin resistance and future risk of metabolic disease. This methodology enables objective assessment of dietary patterns in European child populations, complementary to traditional questionary methods, and can be used in future studies to evaluate diet quality. Moreover, this knowledge can provide mechanistic evidence of common biological pathways that characterize healthy and unhealthy dietary patterns, and diet-related molecular alterations that could associate to metabolic disease.
Issue Date: 25-Jan-2022
Date of Acceptance: 2-Jan-2022
URI: http://hdl.handle.net/10044/1/93992
DOI: 10.7554/eLife.71332
ISSN: 2050-084X
Publisher: eLife Sciences Publications Ltd
Start Page: 1
End Page: 20
Journal / Book Title: eLife
Volume: 11
Copyright Statement: © Stratakis et al. This article is distributed under the terms of the Creative Commons Attribution License, which permits unrestricted use and redistribution provided that the original author and source are credited.
Sponsor/Funder: Medical Research Council (MRC)
Medical Research Council (MRC)
Commission of the European Communities
Commission of the European Communities
Commission of the European Communities
Funder's Grant Number: MR/M501669/1
EP/V520354/1
77454
874583
308333
Keywords: NMR spectroscopy
epidemiology
european children
global health
human
mediterranean diet adherence
metabolomics
ultra-processed food intake
0601 Biochemistry and Cell Biology
Publication Status: Published
Open Access location: https://elifesciences.org/articles/71332
Online Publication Date: 2022-01-25
Appears in Collections:Department of Metabolism, Digestion and Reproduction
Department of Surgery and Cancer
Faculty of Medicine
School of Public Health



This item is licensed under a Creative Commons License Creative Commons