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SARS-CoV-2-host cell surface interactions and potential antiviral therapies

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Title: SARS-CoV-2-host cell surface interactions and potential antiviral therapies
Authors: Butnariu, A-B
Look, A
Grillo, M
Tabish, TA
McGarvey, MJ
Pranjol, MZ
Item Type: Journal Article
Abstract: In this review, we reveal the latest developments at the interface between SARS-CoV-2 and the host cell surface. In particular, we evaluate the current and potential mechanisms of binding, fusion and the conformational changes of the spike (S) protein to host cell surface receptors, especially the human angiotensin-converting enzyme 2 (ACE2) receptor. For instance, upon the initial attachment, the receptor binding domain of the S protein forms primarily hydrogen bonds with the protease domain of ACE2 resulting in conformational changes within the secondary structure. These surface interactions are of paramount importance and have been therapeutically exploited for antiviral design, such as monoclonal antibodies. Additionally, we provide an insight into novel therapies that target viral non-structural proteins, such as viral RNA polymerase. An example of which is remdesivir which has now been approved for use in COVID-19 patients by the US Food and Drug Administration. Establishing further understanding of the molecular details at the cell surface will undoubtably aid the development of more efficacious and selectively targeted therapies to reduce the burden of COVID-19.
Issue Date: 10-Dec-2021
Date of Acceptance: 13-Oct-2021
URI: http://hdl.handle.net/10044/1/93914
DOI: 10.1098/rsfs.2020.0081
ISSN: 2042-8901
Publisher: The Royal Society
Start Page: 1
End Page: 9
Journal / Book Title: Interface Focus
Volume: 12
Issue: 1
Copyright Statement: © 2021 The Authors. Published by the Royal Society under the terms of the Creative Commons Attribution License http://creativecommons.org/licenses/by/4.0/, which permits unrestricted use, provided the original author and source are credited.
Keywords: Science & Technology
Life Sciences & Biomedicine
Biology
Life Sciences & Biomedicine - Other Topics
COVID-19
spike protein
ACE2
antivirals
monoclonal antibody
RESPIRATORY SYNDROME CORONAVIRUS
SARS-CORONAVIRUS
FUNCTIONAL RECEPTOR
SPIKE PROTEIN
FUSION
BINDING
HEMAGGLUTININ
2019-NCOV
REMDESIVIR
ACE2
COVID-19
antivirals
monoclonal antibody
spike protein
Science & Technology
Life Sciences & Biomedicine
Biology
Life Sciences & Biomedicine - Other Topics
COVID-19
spike protein
ACE2
antivirals
monoclonal antibody
RESPIRATORY SYNDROME CORONAVIRUS
SARS-CORONAVIRUS
FUNCTIONAL RECEPTOR
SPIKE PROTEIN
FUSION
BINDING
HEMAGGLUTININ
2019-NCOV
REMDESIVIR
Publication Status: Published
Open Access location: https://royalsocietypublishing.org/doi/full/10.1098/rsfs.2020.0081
Article Number: ARTN 20200081
Online Publication Date: 2021-12-10
Appears in Collections:Materials
Department of Infectious Diseases
Faculty of Medicine
Imperial College London COVID-19



This item is licensed under a Creative Commons License Creative Commons