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Early life inter-kingdom interactions shape the immunological environment of the airways

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Title: Early life inter-kingdom interactions shape the immunological environment of the airways
Authors: Pattaroni, C
Macowan, M
Chatzis, R
Daunt, C
Custovic, A
Shields, MD
Power, UF
Grigg, J
Roberts, G
Ghazal, P
Schwarze, J
Gore, M
Turner, S
Bush, A
Saglani, S
Lloyd, C
Marsland, BJ
Item Type: Journal Article
Abstract: Background: There is increasing evidence that the airway microbiome plays a key role in the establishment of respiratory health by interacting with the developing immune system early in life. While it has become clear that bacteria are involved in this process, there is a knowledge gap concerning the role of fungi. Moreover, the inter-kingdom interactions that influence immune development remain unknown. In this prospective exploratory human study, we aimed to determine early post-natal microbial and immunological features of the upper airways in 121 healthy newborns. Results: We found that the oropharynx and nasal cavity represent distinct ecological niches for bacteria and fungi. Breastfeeding correlated with changes in microbiota composition of oropharyngeal samples with the greatest impact upon the relative abundance of Streptococcus species and Candida. Host transcriptome profiling revealed that genes with the highest expression variation were immunological in nature. Multi-omics factor analysis of host and microbial data revealed unique co-variation patterns. Conclusion: These data provide evidence of a diverse multi-kingdom microbiota linked with local immunological characteristics in the first week of life that could represent distinct trajectories for future respiratory health.
Issue Date: 21-Feb-2022
Date of Acceptance: 12-Nov-2021
URI: http://hdl.handle.net/10044/1/93911
DOI: 10.1186/s40168-021-01201-y
ISSN: 2049-2618
Publisher: BioMed Central
Journal / Book Title: Microbiome
Volume: 10
Issue: 34
Copyright Statement: © The Author(s) 2022. Open Access This article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons licence, and indicate if changes were made. The images or other third party material in this article are included in the article’s Creative Commons licence, unless indicated otherwise in a credit line to the material. If material is not included in the article’s Creative Commons licence and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this licence, visit http://creativecommons.org/licenses/by/4.0/. The Creative Commons Public Domain Dedication waiver (http://creativeco mmons.org/publicdomain/zero/1.0/) applies to the data made available in this article, unless otherwise stated in a credit line to the data.
Sponsor/Funder: Wellcome Trust
Funder's Grant Number: 108818/Z/15/Z and 108818/Z/15/
Keywords: 0602 Ecology
0605 Microbiology
1108 Medical Microbiology
Publication Status: Published
Appears in Collections:National Heart and Lung Institute
Faculty of Medicine

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