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The ReIMAGINE multimodal warehouse: using artificial intelligence for accurate risk stratification of prostate cancer

Title: The ReIMAGINE multimodal warehouse: using artificial intelligence for accurate risk stratification of prostate cancer
Authors: Santaolalla, A
Hulsen, T
Davis, J
Ahmed, HU
Moore, CM
Punwani, S
Attard, G
McCartan, N
Emberton, M
Coolen, A
Van Hemelrijck, M
Item Type: Journal Article
Abstract: Introduction. Prostate cancer (PCa) is the most frequent cancer diagnosis in men worldwide. Our ability to identify those men whose cancer will decrease their lifespan and/or quality of life remains poor. The ReIMAGINE Consortium has been established to improve PCa diagnosis. Materials and methods. MRI will likely become the future cornerstone of the risk-stratification process for men at risk of early prostate cancer. We will, for the first time, be able to combine the underlying molecular changes in PCa with the state-of-the-art imaging. ReIMAGINE Screening invites men for MRI and PSA evaluation. ReIMAGINE Risk includes men at risk of prostate cancer based on MRI, and includes biomarker testing. Results. Baseline clinical information, genomics, blood, urine, fresh prostate tissue samples, digital pathology and radiomics data will be analysed. Data will be de-identified, stored with correlated mpMRI disease endotypes and linked with long term follow-up outcomes in an instance of the Philips Clinical Data Lake, consisting of cloud-based software. The ReIMAGINE platform includes application programming interfaces and a user interface that allows users to browse data, select cohorts, manage users and access rights, query data, and more. Connection to analytics tools such as Python allows statistical and stratification method pipelines to run profiling regression analyses. Discussion. The ReIMAGINE Multimodal Warehouse comprises a unique data source for PCa research, to improve risk stratification for PCa and inform clinical practice. The de-identified dataset characterized by clinical, imaging, genomics and digital pathology PCa patient phenotypes will be a valuable resource for the scientific and medical community.
Issue Date: 16-Nov-2021
Date of Acceptance: 12-Oct-2021
URI: http://hdl.handle.net/10044/1/93501
DOI: 10.3389/frai.2021.769582
ISSN: 2624-8212
Publisher: Frontiers Media
Journal / Book Title: Frontiers in Artificial Intelligence
Volume: 4
Copyright Statement: © 2021 Santaolalla, Hulsen, Davis, Ahmed, Moore, Punwani, Attard, McCartan, Emberton, Coolen and Van Hemelrijck. This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) and the copyright owner(s) are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms.
Sponsor/Funder: Medical Research Council (MRC)
Medical Research Council (MRC)
Funder's Grant Number: WSST_P70374
EP/V520354/1
Keywords: artificial intelligence
data integration
data management
data science
data warehouse
database
prostate cancer
risk stratification
artificial intelligence
data integration
data management
data science
data warehouse
database
prostate cancer
risk stratification
Publication Status: Published
Conference Place: Switzerland
Article Number: ARTN 769582
Appears in Collections:Department of Surgery and Cancer
Faculty of Medicine



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