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Blood n-3 fatty acid levels and total and cause-specific mortality from 17 prospective studies

Title: Blood n-3 fatty acid levels and total and cause-specific mortality from 17 prospective studies
Authors: Harris, WS
Tintle, NL
Imamura, F
Qian, F
Korat, AVA
Marklund, M
Djousse, L
Bassett, JK
Carmichael, P-H
Chen, Y-Y
Hirakawa, Y
Kupers, LK
Laguzzi, F
Lankinen, M
Murphy, RA
Samieri, C
Senn, MK
Shi, P
Virtanen, JK
Brouwer, IA
Chien, K-L
Eiriksdottir, G
Forouhi, NG
Geleijnse, JM
Giles, GG
Gudnason, V
Helmer, C
Hodge, A
Jackson, R
Khaw, K-T
Laakso, M
Lai, H
Laurin, D
Leander, K
Lindsay, J
Micha, R
Mursu, J
Ninomiya, T
Post, W
Psaty, BM
Riserus, U
Robinson, JG
Shadyab, AH
Snetselaar, L
Sala-Vila, A
Sun, Y
Steffen, LM
Tsai, MY
Wareham, NJ
Wood, AC
Wu, JHY
Hu, F
Sun, Q
Siscovick, DS
Lemaitre, RN
Mozaffarian, D
Item Type: Journal Article
Abstract: The health effects of omega-3 fatty acids have been controversial. Here we report the results of a de novo pooled analysis conducted with data from 17 prospective cohort studies examining the associations between blood omega-3 fatty acid levels and risk for all-cause mortality. Over a median of 16 years of follow-up, 15,720 deaths occurred among 42,466 individuals. We found that, after multivariable adjustment for relevant risk factors, risk for death from all causes was significantly lower (by 15–18%, at least p < 0.003) in the highest vs the lowest quintile for circulating long chain (20–22 carbon) omega-3 fatty acids (eicosapentaenoic, docosapentaenoic, and docosahexaenoic acids). Similar relationships were seen for death from cardiovascular disease, cancer and other causes. No associations were seen with the 18-carbon omega-3, alpha-linolenic acid. These findings suggest that higher circulating levels of marine n-3 PUFA are associated with a lower risk of premature death.
Issue Date: 22-Apr-2021
Date of Acceptance: 1-Mar-2021
URI: http://hdl.handle.net/10044/1/93345
DOI: 10.1038/s41467-021-22370-2
ISSN: 2041-1723
Publisher: Nature Research
Journal / Book Title: Nature Communications
Volume: 12
Issue: 1
Copyright Statement: © The Author(s) 2021
Keywords: Science & Technology
Multidisciplinary Sciences
Science & Technology - Other Topics
ALL-CAUSE MORTALITY
CORONARY-HEART-DISEASE
LONG-CHAIN OMEGA-3-FATTY-ACIDS
CARDIOVASCULAR-DISEASE
DOCOSAHEXAENOIC ACID
FISH CONSUMPTION
ADIPOSE-TISSUE
RISK
ASSOCIATION
BIOMARKERS
Aged
Aged, 80 and over
Cause of Death
Fatty Acids, Omega-3
Female
Follow-Up Studies
Humans
Male
Middle Aged
Mortality, Premature
Prospective Studies
Protective Factors
Risk Factors
Fatty Acids and Outcomes Research Consortium (FORCE)
Humans
Fatty Acids, Omega-3
Cause of Death
Risk Factors
Follow-Up Studies
Prospective Studies
Aged
Aged, 80 and over
Middle Aged
Female
Male
Mortality, Premature
Protective Factors
Science & Technology
Multidisciplinary Sciences
Science & Technology - Other Topics
ALL-CAUSE MORTALITY
CORONARY-HEART-DISEASE
LONG-CHAIN OMEGA-3-FATTY-ACIDS
CARDIOVASCULAR-DISEASE
DOCOSAHEXAENOIC ACID
FISH CONSUMPTION
ADIPOSE-TISSUE
RISK
ASSOCIATION
BIOMARKERS
Publication Status: Published
Article Number: ARTN 2329
Online Publication Date: 2021-04-22
Appears in Collections:Faculty of Medicine
School of Public Health



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