6
IRUS Total
Downloads

Neurolymphomatosis of multifocal peripheral nerve involvement: a case report

File Description SizeFormat 
81332-PB10-6220-R2.pdfPublished version5.85 MBAdobe PDFView/Open
Title: Neurolymphomatosis of multifocal peripheral nerve involvement: a case report
Authors: Peng, L
Yang, H
Zhao, Y
He, J
Stebbing, J
Chen, B
Item Type: Journal Article
Abstract: The infiltration and invasion of nerve trunks, nerve roots, and cranial nerves by lymphomatous malignant cells is defined as “neurolymphomatosis”. It is mainly caused by lymphoma cells directly infiltrating the peripheral nerves, with a low incidence. Neurolymphomatosis is a rare condition of neoplastic endoneurial invasion, which is primary or secondary to non-Hodgkin’s lymphoma and leukemia. We describe a case of primary peripheral neurolymphomatosis of multifocal involvement in a 77-year-old male patient. He presented with left lower limb pain and was diagnosed with CD20+ diffuse large B cell lymphoma (DLBCL). Magnetic resonance imaging (MRI), fluorine-18 fluorodeoxyglucose (18F-FDG) positron emission tomography (PET) computed tomography (CT), and nerve biopsy contributed to the diagnosis. Genomic profiling, programmed death ligand-1 (PD-L1) expression and tumor mutational burden (TMB) were also assessed. CDKN2A/CDKN2B deletions have been identified. PD-L1 expression assessed by 28-8 antibody was 1% positivity, and TMB of the sample was 11.6 muts/Mb. The patient responded well to rituximab combined with chemotherapy, however, he died after 3 cycles of chemotherapy due to severe lung infection and subsequent complication of respiratory failure. Here we report the clinical, radiological, pathological and molecular findings of the patient affected by multifocal neurolymphomatosis without systemic involvement of other organs.
Issue Date: 1-Jul-2022
Date of Acceptance: 30-Sep-2021
URI: http://hdl.handle.net/10044/1/93284
DOI: 10.21037/apm-21-2256
ISSN: 2224-5820
Publisher: AME Publishing
Start Page: 2529
End Page: 2537
Journal / Book Title: Annals of Palliative Medicine
Volume: 11
Issue: 7
Copyright Statement: © Annals of Palliative Medicine. All rights reserved. This is an Open Access article distributed in accordance with the Creative Commons Attribution-NonCommercial-NoDerivs 4.0 International License (CC BY-NC-ND 4.0), which permits the noncommercial replication and distribution of the article with the strict proviso that no changes or edits are made and the original work is properly cited (including links to both the formal publication through the relevant DOI and the license). See: https://creativecommons.org/licenses/by-nc-nd/4.0/.
Sponsor/Funder: National Institute for Health Research
Imperial College Healthcare NHS Trust- BRC Funding
Funder's Grant Number: NIHR-RP-011-053
RDB01 79560
Keywords: Science & Technology
Life Sciences & Biomedicine
Health Care Sciences & Services
Neurolymphomatosis
lymphoma
peripheral nerve
next generation sequencing (NGS)
case report
LYMPHOMA
CDKN2A
GENE
Neurolymphomatosis
case report
lymphoma
next generation sequencing (NGS)
peripheral nerve
Science & Technology
Life Sciences & Biomedicine
Health Care Sciences & Services
Neurolymphomatosis
lymphoma
peripheral nerve
next generation sequencing (NGS)
case report
LYMPHOMA
CDKN2A
GENE
Publication Status: Published
Online Publication Date: 2021-09-30
Appears in Collections:Department of Surgery and Cancer
Faculty of Medicine



This item is licensed under a Creative Commons License Creative Commons