Defend or reproduce? Muscle-derived glutamate determines an immune/reproductive energetic tradeoff

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Title: Defend or reproduce? Muscle-derived glutamate determines an immune/reproductive energetic tradeoff
Authors: Mineo, A
Miguel-Aliaga, I
Item Type: Journal Article
Abstract: There are dramatic disparities in infection susceptibility within populations. In this issue of Cell Metabolism, Zhao and Karpac uncover a muscle-adipose-gut axis in Drosophila that explains variability in pathogen susceptibility. The degree of intramuscular NF-kB activation accounts for differences in circulating glutamate, which enhances resistance at the expense of reproduction.
Issue Date: 7-Dec-2021
Date of Acceptance: 12-Nov-2021
URI: http://hdl.handle.net/10044/1/92983
DOI: 10.1016/j.cmet.2021.11.007
ISSN: 1550-4131
Publisher: Cell Press
Start Page: 2307
End Page: 2309
Journal / Book Title: Cell Metabolism
Volume: 33
Issue: 12
Copyright Statement: © 2021 Elsevier Inc. All rights reserved. This manuscript is licensed under the Creative Commons Attribution-NonCommercial-NoDerivatives 4.0 International Licence http://creativecommons.org/licenses/by-nc-nd/4.0/
Sponsor/Funder: Commission of the European Communities
Funder's Grant Number: 787470
Keywords: 0601 Biochemistry and Cell Biology
1101 Medical Biochemistry and Metabolomics
Endocrinology & Metabolism
Publication Status: Published
Embargo Date: 2022-12-06
Online Publication Date: 2021-12-07
Appears in Collections:Institute of Clinical Sciences



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