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Defend or reproduce? Muscle-derived glutamate determines an immune/reproductive energetic tradeoff
| File | Description | Size | Format | |
|---|---|---|---|---|
 karpac previewIMAAM8.pdf | Accepted version | 374.89 kB | Adobe PDF | View/Open |
| Title: | Defend or reproduce? Muscle-derived glutamate determines an immune/reproductive energetic tradeoff |
| Authors: | Mineo, A Miguel-Aliaga, I |
| Item Type: | Journal Article |
| Abstract: | There are dramatic disparities in infection susceptibility within populations. In this issue of Cell Metabolism, Zhao and Karpac uncover a muscle-adipose-gut axis in Drosophila that explains variability in pathogen susceptibility. The degree of intramuscular NF-kB activation accounts for differences in circulating glutamate, which enhances resistance at the expense of reproduction. |
| Issue Date: | 7-Dec-2021 |
| Date of Acceptance: | 12-Nov-2021 |
| URI: | http://hdl.handle.net/10044/1/92983 |
| DOI: | 10.1016/j.cmet.2021.11.007 |
| ISSN: | 1550-4131 |
| Publisher: | Cell Press |
| Start Page: | 2307 |
| End Page: | 2309 |
| Journal / Book Title: | Cell Metabolism |
| Volume: | 33 |
| Issue: | 12 |
| Copyright Statement: | © 2021 Elsevier Inc. All rights reserved. This manuscript is licensed under the Creative Commons Attribution-NonCommercial-NoDerivatives 4.0 International Licence http://creativecommons.org/licenses/by-nc-nd/4.0/ |
| Sponsor/Funder: | Commission of the European Communities |
| Funder's Grant Number: | 787470 |
| Keywords: | 0601 Biochemistry and Cell Biology 1101 Medical Biochemistry and Metabolomics Endocrinology & Metabolism |
| Publication Status: | Published |
| Online Publication Date: | 2021-12-07 |
| Appears in Collections: | Institute of Clinical Sciences |
This item is licensed under a Creative Commons License
