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Insights from IgE immune surveillance in allergy and cancer for anti-tumour IgE treatments

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Title: Insights from IgE immune surveillance in allergy and cancer for anti-tumour IgE treatments
Authors: McCraw, AJ
Chauhan, J
Bax, HJ
Stavraka, C
Osborn, G
Grandits, M
López-Abente, J
Josephs, DH
Spicer, J
Wagner, GK
Karagiannis, SN
Chenoweth, A
Crescioli, S
Item Type: Journal Article
Abstract: IgE, the predominant antibody class of the allergic response, is known for its roles in protecting against parasites; however, a growing body of evidence indicates a significant role for IgE and its associated effector cells in tumour immunosurveillance, highlighted by the field of AllergoOncology and the successes of the first-in-class IgE cancer therapeutic MOv18. Supporting this concept, substantial epidemiological data ascribe potential roles for IgE, allergy, and atopy in protecting against specific tumour types, with a corresponding increased cancer risk associated with IgE immunodeficiency. Here, we consider how epidemiological data in combination with functional data reveals a complex interplay of IgE and allergy with cancer, which cannot be explained solely by one of the existing conventional hypotheses. We furthermore discuss how, in turn, such data may be used to inform future therapeutic approaches, including the clinical management of different patient groups. With epidemiological findings highlighting several high-risk cancer types protected against by high IgE levels, it is possible that use of IgE-based therapeutics for a range of malignant indications may offer efficacy to complement that of established IgG-class antibodies.
Issue Date: 4-Sep-2021
Date of Acceptance: 1-Sep-2021
URI: http://hdl.handle.net/10044/1/91783
DOI: 10.3390/cancers13174460
ISSN: 2072-6694
Journal / Book Title: Cancers (Basel)
Volume: 13
Issue: 17
Copyright Statement: © 2021 by the authors.Licensee MDPI, Basel, Switzerland.This article is an open access articledistributed under the terms andconditions of the Creative CommonsAttribution (CC BY) license (https://creativecommons.org/licenses/by/4.0/).
Keywords: AllergoOncology
IgE
antibodies
cancer
immunotherapy
AllergoOncology
IgE
antibodies
cancer
immunotherapy
1112 Oncology and Carcinogenesis
Publication Status: Published
Conference Place: Switzerland
Open Access location: https://www.mdpi.com/2072-6694/13/17/4460
Article Number: ARTN 4460
Appears in Collections:Department of Surgery and Cancer



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