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Trends in mortality from aortic stenosis in Europe: 2000-2017

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Title: Trends in mortality from aortic stenosis in Europe: 2000-2017
Authors: Hartley, A
Shalhoub, J
Khamis, R
Item Type: Journal Article
Abstract: Background Trends in mortality from aortic stenosis across European countries are not well understood, especially given the significant growth in transcatheter aortic valve implantation (TAVI) in the last 10 years. Methods Age-standardised death rates were extracted from the World Health Organisation Mortality Database, using the International Classification of Diseases 10th edition code for non-rheumatic aortic stenosis for those aged >45 years between 2000 and 2017. The UK and countries from the European Union with at least 1,000,000 inhabitants and at least 50% available datapoints over the study period were included: a total of 23 countries. Trends were described using Joinpoint regression analysis. Results No reductions in mortality were demonstrated across all countries 2000-2017. Large increases in mortality were found for Croatia, Poland and Slovakia for both sexes (>300% change). Mortality plateaued in Germany from 2008 in females and 2012 in males, whilst mortality in the Netherlands declined for both sexes from 2007. Mortality differences between the sexes were observed, with greater mortality for males than females across most countries. Conclusions Mortality from aortic stenosis has increased across Europe from 2000 to 2017. There are, however, sizable differences in mortality trends between Eastern and Western European countries. The need for health resource planning strategies to specifically target AS, particularly given the expected increase with aging populations, is highlighted.
Issue Date: 11-Oct-2021
Date of Acceptance: 15-Sep-2021
URI: http://hdl.handle.net/10044/1/91742
DOI: 10.3389/fcvm.2021.748137
ISSN: 2297-055X
Publisher: Frontiers Media
Start Page: 1
End Page: 9
Journal / Book Title: Frontiers in Cardiovascular Medicine
Volume: 8
Copyright Statement: © 2021 Hartley, Hammond-Haley, Marshall, Salciccioli, Malik, Khamis and Shalhoub. This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) and the copyright owner(s) are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms.
Sponsor/Funder: Wellcome Trust
British Heart Foundation
Funder's Grant Number: FS/17/16/32560
Keywords: Europe
aortic stenosis
aortic valve replacement (AVR)
mortality
transcatheter aortic valve implantation (TAVI)
Publication Status: Published
Article Number: 748137
Online Publication Date: 2021-10-11
Appears in Collections:Department of Surgery and Cancer
National Heart and Lung Institute
Faculty of Medicine



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