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Clinical and biological features of cerebral venous sinus thrombosis following ChAdOx1 nCov-19 vaccination
| File | Description | Size | Format | |
|---|---|---|---|---|
 Clinical and biological features of cerebral venous sinus thrombosis following ChAdOx1 nCov-19 Vaccination.pdf | Accepted version | 276.58 kB | Adobe PDF | View/Open |
| Supplementary Material 08.08.21.pdf | Supporting information | 1.38 MB | Adobe PDF | View/Open |
| Title: | Clinical and biological features of cerebral venous sinus thrombosis following ChAdOx1 nCov-19 vaccination |
| Authors: | Crossette-Thambiah, C Pericleous, C Asmar, N Bomsztyk, J Ranger, A Shlebak, A Ramji, S Banerjee, S Laffan, M Jayakody Arachchillage, D |
| Item Type: | Journal Article |
| Abstract: | Vaccines for COVID-19were developed with unprecedented speedand since January 2021, the AstraZeneca/Oxford University ChAdOx1 nCoV-19 vaccine has been administered to over 400 million people globally1. In April 2021, the Medicines and Healthcare products Regulatory Agency (MHRA) and the European Medicines Agency (EMA)reported a possible association between ChAdOx1 nCoV-19 and a rare syndrome of unusual site thrombosis combined with thrombocytopenia, termed vaccine-induced immune thrombotic thrombocytopenia (VITT).Frequency of VITT varies across age groups. Overall 411 cases of VITT have been reported to Medicine & Healthcare prodcuts Regulatory Agency (MHRA) by 21st of July 2021 with fatality rate of 17.76% (73/411)2. |
| Issue Date: | 14-Mar-2022 |
| Date of Acceptance: | 26-Aug-2021 |
| URI: | http://hdl.handle.net/10044/1/91313 |
| DOI: | 10.1136/jnnp-2021-327340 |
| ISSN: | 0022-3050 |
| Publisher: | BMJ Publishing Group |
| Start Page: | 445 |
| End Page: | 448 |
| Journal / Book Title: | Journal of Neurology, Neurosurgery and Psychiatry |
| Volume: | 93 |
| Issue: | 4 |
| Copyright Statement: | © Author(s) (or their employer(s)) 2022. No commercial re-use. See rights and permissions. Published by BMJ. This article is made freely available for personal use in accordance with BMJ’s website terms and conditions for the duration of the covid-19 pandemic or until otherwise determined by BMJ. You may use, download and print the article for any lawful, non-commercial purpose (including text and data mining) provided that all copyright notices and trade marks are retained. This article has been accepted for publication in Journal of Neurology, Neurosurgery & Psychiatry following peer review. The definitive copyedited, typeset version Crossette-Thambiah C, Pericleous C, Asmar N, et alClinical and biological features of cerebral venous sinus thrombosis following ChAdOx1 nCov-19 vaccinationJournal of Neurology, Neurosurgery & Psychiatry 2022;93:445-448 is available online at: http://dx.doi.org/10.1136/jnnp-2021-327340 |
| Keywords: | Science & Technology Life Sciences & Biomedicine Clinical Neurology Psychiatry Surgery Neurosciences & Neurology COVID-19 sinus thrombosis COVID-19 sinus thrombosis Neurology & Neurosurgery 11 Medical and Health Sciences 17 Psychology and Cognitive Sciences |
| Publication Status: | Published |
| Online Publication Date: | 2021-09-29 |
| Appears in Collections: | Department of Immunology and Inflammation Faculty of Medicine |