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Histone post-translational modification as potential therapeutic targets for pain management

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Title: Histone post-translational modification as potential therapeutic targets for pain management
Authors: Torres Perez, J
Irfan, J
Febrianto, MR
Di Giovanni, S
Nagy, I
Item Type: Journal Article
Abstract: Effective pharmacological management of pain associated with tissue unmet medical need. Transcriptional modifications in nociceptive pathways are pivotal for the development and the maintenance of pain associated with tissue damage. Accumulating evidence has shown the importance of the epigenetic control of transcription within nociceptive pathways via histone post-translational modifications (PTMs). Hence, histone PTMs could be targets for novel effective analgesics. Here, we discuss the current understanding of histone PTMs in the modulation of gene expression affecting nociception and pain phenotypes following tissue injury. We also provide a critical view of the translational implications of preclinical models and discuss opportunities and challenges of targeting histone PTMs for relieving pain in clinically relevant tissue injuries.
Issue Date: 1-Nov-2021
Date of Acceptance: 18-Aug-2021
URI: http://hdl.handle.net/10044/1/91287
DOI: 10.1016/j.tips.2021.08.002
ISSN: 0165-6147
Publisher: Cell Press
Start Page: 897
End Page: 911
Journal / Book Title: Trends in Pharmacological Sciences
Volume: 42
Issue: 11
Copyright Statement: © 2021 The Author(s). Published by Elsevier Ltd. This is an open access article under the CC BY license (http://creativecommons.org/licenses/by/4.0/)
Keywords: dorsal root ganglion
epigenetics
gene transcription
neuropathic pain
nociception
spinal dorsal horn
06 Biological Sciences
11 Medical and Health Sciences
Pharmacology & Pharmacy
Publication Status: Published
Online Publication Date: 2021-09-23
Appears in Collections:Department of Surgery and Cancer
Faculty of Medicine
Department of Brain Sciences



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