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Understanding lower limb muscle volume adaptations to amputation.

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Title: Understanding lower limb muscle volume adaptations to amputation.
Authors: Henson, DP
Edgar, C
Ding, Z
Sivapuratharasu, B
Le Feuvre, P
Finnegan, ME
Quest, R
McGregor, AH
Bull, AMJ
Item Type: Journal Article
Abstract: Amputation of a major limb, and the subsequent return to movement with a prosthesis, requires the development of compensatory strategies to account for the loss. Such strategies, over time, lead to regional muscle atrophy and hypertrophy through chronic under or overuse of muscles compared to uninjured individuals. The aim of this study was to quantify the lower limb muscle parameters of persons with transtibial and transfemoral amputations using high resolution MRI to ascertain muscle volume and to determine regression equations for predicting muscle volume using femur- and tibia-length, pelvic-width, height, and mass. Twelve persons with limb loss participated in this study and their data were compared to six matched control subjects. Subjects with unilateral transtibial amputation showed whole-limb muscle volume loss in the residual-limb, whereas minor volume changes in the intact limb were found, providing evidence for a compensation strategy that is dominated by the intact-limb. Subjects with bilateral-transfemoral amputations showed significant muscle volume increases in the short adductor muscles with an insertion not affected by the amputation, the hip flexors, and the gluteus medius, and significant volume decreases in the longer adductor muscles, rectus femoris, and hamstrings. This study presents a benchmark measure of muscle volume discrepancies in persons with limb-loss, and can be used to understand the compensation strategies of persons with limb-loss and the impact on muscle volume, thus enabling the development of optimised intervention protocols, conditioning therapies, surgical techniques, and prosthetic devices that promote and enhance functional capability within the population of persons with limb loss.
Issue Date: 26-Aug-2021
Date of Acceptance: 24-Jun-2021
URI: http://hdl.handle.net/10044/1/90811
DOI: 10.1016/j.jbiomech.2021.110599
ISSN: 0021-9290
Publisher: Elsevier
Start Page: 1
End Page: 8
Journal / Book Title: Journal of Biomechanics
Volume: 125
Copyright Statement: © 2021 The Authors. Published by Elsevier Ltd. This is an open access article under the CC BY-NC-ND license (http://creativecommons.org/licenses/by-nc-nd/4.0/).
Sponsor/Funder: The Royal British Legion
Funder's Grant Number: Centre for Blast Injury Studie
Keywords: Amputation
Amputee
Muscle
Muscle volume
Musculoskeletal
Amputation
Amputee
Muscle
Muscle volume
Musculoskeletal
0903 Biomedical Engineering
0913 Mechanical Engineering
1106 Human Movement and Sports Sciences
Biomedical Engineering
Publication Status: Published
Conference Place: United States
Online Publication Date: 2021-06-29
Appears in Collections:Bioengineering
Department of Surgery and Cancer
Faculty of Medicine



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