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Bidirectional bioelectronic interfaces: system design and circuit implications

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Title: Bidirectional bioelectronic interfaces: system design and circuit implications
Authors: Liu, Y
Urso, A
Martins da Ponte, R
Costa, T
Valente, V
Giagka, V
Serdijn, WA
Constandinou, TG
Denison, T
Item Type: Journal Article
Abstract: The total economic cost of neurological disorders exceeds £100 billion per annum in the United Kingdom alone, yet pharmaceutical companies continue to cut investments due to failed clinical studies and risk [1]. These challenges motivate an alternative to solely pharmacological treatments. The emerging field of bioelectronics suggests a novel alternative to pharmaceutical intervention that uses electronic hardware to directly stimulate the nervous system with physiologically inspired electrical signals [2]. Given the processing capability of electronics and precise targeting of electrodes, the potential advantages of bioelectronics include specificity in the time, method, and location of treatment, with the ability to iteratively refine and update therapy algorithms in software [3]. A primary disadvantage of the current systems is invasiveness due to surgical implantation of the device.
Issue Date: 23-Jun-2020
Date of Acceptance: 15-May-2020
URI: http://hdl.handle.net/10044/1/90718
DOI: 10.1109/mssc.2020.2987506
ISSN: 1943-0582
Publisher: Institute of Electrical and Electronics Engineers (IEEE)
Start Page: 30
End Page: 46
Journal / Book Title: IEEE Solid-State Circuits Magazine
Volume: 12
Issue: 2
Copyright Statement: © 2020 IEEE. Personal use of this material is permitted. Permission from IEEE must be obtained for all other uses, in any current or future media, including reprinting/republishing this material for advertising or promotional purposes, creating new collective works, for resale or redistribution to servers or lists, or reuse of any copyrighted component of this work in other works. See http://www.ieee.org/publications_standards/publications/rights/index.html for more information.
Sponsor/Funder: Wellcome Trust
Engineering & Physical Science Research Council (EPSRC)
Funder's Grant Number: BH134389
Publication Status: Published
Appears in Collections:Electrical and Electronic Engineering