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The effect of decongestion on nasal airway patency and airflow

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Title: The effect of decongestion on nasal airway patency and airflow
Authors: Doorly, D
Xiao, Q
Bates, A
Cetto, R
Item Type: Journal Article
Abstract: Nasal decongestant reduces blood flow to the nasal turbinates, reducing tissue volume and increasing nasal airway patency. This study maps the changes in nasal anatomy and measures how these changes affect nasal resistance, flow partitioning between superior and inferior cavity, flow patterns and wall shear stress. High-resolution MRI was applied to capture nasal anatomy in 10 healthy subjects before and after application of a topical decongestant. Computational fluid dynamics simulated nasal airflow at steady inspiratory flow rates of 15 L.min−1 and 30 L.min−1. The results show decongestion mainly increases the cross-sectional area in the turbinate region and SAVR is reduced (median approximately 40% reduction) in middle and lower parts of the cavity. Decongestion reduces nasal resistance by 50% on average, while in the posterior cavity, nasal resistance decreases by a median factor of approximately 3 after decongestion. We also find decongestant regularises nasal airflow and alters the partitioning of flow, significantly decreasing flow through the superior portions of the nasal cavity. By comparing nasal anatomies and airflow in their normal state with that when pharmacologically decongested, this study provides data for a broad range of anatomy and airflow conditions, which may help characterize the extent of nasal variability.
Issue Date: 13-Jul-2021
Date of Acceptance: 28-Jun-2021
URI: http://hdl.handle.net/10044/1/90717
DOI: 10.1038/s41598-021-93769-6
ISSN: 2045-2322
Publisher: Springer
Start Page: 1
End Page: 13
Journal / Book Title: Nature Scientific Reports
Volume: 11
Issue: 14410
Copyright Statement: © The Author(s) 2021. Open Access This article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons licence, and indicate if changes were made. The images or other third party material in this article are included in the article's Creative Commons licence, unless indicated otherwise in a credit line to the material. If material is not included in the article's Creative Commons licence and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this licence, visit http://creativecommons.org/licenses/by/4.0/.
Publication Status: Published
Online Publication Date: 2021-07-13
Appears in Collections:Aeronautics

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