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Azole-resistant Aspergillus fumigatus is highly prevalent in the environment of Vietnam, with marked variability by land use type

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Title: Azole-resistant Aspergillus fumigatus is highly prevalent in the environment of Vietnam, with marked variability by land use type
Authors: Duong, T-MN
Le, T-V
Tran, K-LH
Nguyen, P-T
Nguyen, B-PT
Nguyen, T-A
Nguyen, H-LP
Nguyen, B-NT
Fisher, MC
Rhodes, J
Marks, G
Fox, GJ
Chen, SC-A
Walsh, MG
Barrs, VR
Talbot, J
Halliday, CL
Sorrell, TC
Day, JN
Beardsley, J
Item Type: Journal Article
Abstract: Azole-resistant environmental Aspergillus fumigatus presents a threat to public health but the extent of this threat in Southeast Asia is poorly described. We conducted environmental surveillance in the Mekong Delta region of Vietnam, collecting air and ground samples across key land-use types, and determined antifungal susceptibilities of Aspergillus section Fumigati (ASF) isolates and azole concentrations in soils. Of 119 ASF isolates, 55% were resistant (or non-wild type) to itraconazole, 65% to posaconazole and 50% to voriconazole. Azole resistance was more frequent in A. fumigatus sensu stricto isolates (95%) than other ASF species (32%). Resistant isolates and agricultural azole residues were overrepresented in samples from cultivated land. cyp51A gene sequence analysis showed 38/56 resistant A. fumigatus sensu stricto isolates carried known resistance mutations, with TR34/L98H most frequent (34/38).
Date of Acceptance: 3-Jul-2021
URI: http://hdl.handle.net/10044/1/90681
DOI: 10.1111/1462-2920.15660
ISSN: 1462-2912
Publisher: Society for Applied Microbiology
Journal / Book Title: Environmental Microbiology
Sponsor/Funder: Medical Research Council (MRC)
Wellcome Trust
Funder's Grant Number: MR/R015600/1
219551/Z/19/Z
Keywords: Science & Technology
Life Sciences & Biomedicine
Microbiology
CYP51A GENE
TR34/L98H MUTATIONS
SECTION FUMIGATI
CYSTIC-FIBROSIS
MECHANISMS
SUSCEPTIBILITY
SURVEILLANCE
BURDEN
Science & Technology
Life Sciences & Biomedicine
Microbiology
CYP51A GENE
TR34/L98H MUTATIONS
SECTION FUMIGATI
CYSTIC-FIBROSIS
MECHANISMS
SUSCEPTIBILITY
SURVEILLANCE
BURDEN
Microbiology
0603 Evolutionary Biology
0605 Microbiology
Publication Status: Published online
Embargo Date: Embargoed for 12 months after publication date
Online Publication Date: 2021-07-07
Appears in Collections:School of Public Health



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