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Metabolic profiling reveals changes in serum predictive of venous ulcer healing

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Title: Metabolic profiling reveals changes in serum predictive of venous ulcer healing
Authors: Bergner, R
Onida, S
Velineni, R
Spagou, K
Gohel, MS
Bouschbacher, M
Bohbot, S
Shalhoub, J
Holmes, E
Davies, AH
Item Type: Journal Article
Abstract: Objective: The aim of this study was to identify potential biomarkers predictive of healing or failure to heal in a population with venous leg ulceration. Summary Background Data: Venous leg ulceration presents important physical, psychological, social and financial burdens. Compression therapy is the main treatment, but it can be painful and time-consuming, with significant recurrence rates. The identification of a reliable biochemical signature with the ability to identify nonhealing ulcers has important translational applications for disease prognostication, personalized health care and the development of novel therapies. Methods: Twenty-eight patients were assessed at baseline and at 20 weeks. Untargeted metabolic profiling was performed on urine, serum, and ulcer fluid, using mass spectrometry and nuclear magnetic resonance spectroscopy. Results: A differential metabolic phenotype was identified in healing (n = 15) compared to nonhealing (n = 13) venous leg ulcer patients. Analysis of the assigned metabolites found ceramide and carnitine metabolism to be relevant pathways. In this pilot study, only serum biofluids could differentiate between healing and nonhealing patients. The ratio of carnitine to ceramide was able to differentiate between healing phenotypes with 100% sensitivity, 79% specificity, and 91% accuracy. Conclusions: This study reports a metabolic signature predictive of healing in venous leg ulceration and presents potential translational applications for disease prognostication and development of targeted therapies.
Issue Date: 21-May-2021
Date of Acceptance: 23-Apr-2021
URI: http://hdl.handle.net/10044/1/90285
DOI: 10.1097/sla.0000000000004933
ISSN: 0003-4932
Publisher: Ovid Technologies (Wolters Kluwer Health)
Journal / Book Title: Annals of Surgery
Keywords: Surgery
11 Medical and Health Sciences
Publication Status: Published online
Online Publication Date: 2021-05-21
Appears in Collections:Department of Metabolism, Digestion and Reproduction
Department of Surgery and Cancer
Faculty of Medicine



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