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Influence of age, gender, smoking, diabetes, thyroid and cardiac dysfunctions on cystatin C biomarker

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Title: Influence of age, gender, smoking, diabetes, thyroid and cardiac dysfunctions on cystatin C biomarker
Authors: Al Musaimi, O
Abu-Nawwas, AH
Al Shaer, D
Khaleel, NY
Fawzi, M
Item Type: Journal Article
Abstract: Background Creatinine is the most widely used renal failure biomarker; however, it has a lot of drawbacks. One of the major drawbacks is the blind range (does not increase until 50% of the kidney deteriorates). On the other hand, cystatin C has gained more attention as a promising biomarker due to several advantages over creatinine. Cystatin C levels are elevated as soon as any mild defect in the kidney occurs. Furthermore, cystatin C is influenced by several non-renal diseases which provide an additional prognostic value for this promising biomarker. Objectives 1. Study the effects of age, gender and smoking on cystatin C levels to. 2. Challenge the adoption of glomerular filtration rate equations for healthy population. 3. Compare the values generated from different glomerular filtration rate equations. 4. Evaluate the prognostic value of cystatin C for selected non-renal diseases. Methods Using cross sectional analyses, we established the relationship between cystatin C levels and non-renal predictors. The quantification of cystatin C was performed by high performance liquid chromatographic method, while for creatinine by a colorimetric enzymatic method. Results In the healthy volunteers the levels of cystatin C were slightly higher in men than in women and in individuals older than 50 years old than those under 50 years old and in smokers than non-smokers, however, statistical data confirmed a non-significant relationship with respect to the aforementioned factors. For the recruited patients suffering from (diabetes, hyper- and hypothyroidism and cardiac dysfunctions) a clear increase in cystatin C levels were observed with the exception of hypothyroidism patients in which a decrease in their cystatin C levels were observed. Conclusion Diabetes, thyroid and cardiac dysfunctions have a clear impact on the levels of cystatin C in human blood, whereas age, gender and smoking habit have no effect. Therefore, cystatin C could be considered as a useful biomarker of the aforementioned diseases, in turn, this requires extra precautions including the evaluation of several clinical conditions by physicians should CC is considered as a renal failure biomarker.
Issue Date: 1-Jan-2019
Date of Acceptance: 4-Jul-2018
URI: http://hdl.handle.net/10044/1/88733
DOI: 10.1016/j.semerg.2018.07.005
ISSN: 1138-3593
Publisher: Elsevier
Start Page: 44
End Page: 51
Journal / Book Title: Semergen - Medicina de Familia
Volume: 45
Issue: 1
Copyright Statement: © 2018 Elsevier Ltd. All rights reserved. This manuscript is licensed under the Creative Commons Attribution-NonCommercial-NoDerivatives 4.0 International Licence http://creativecommons.org/licenses/by-nc-nd/4.0/
Sponsor/Funder: King Abdulaziz City for Science and Technology (KACST)
Funder's Grant Number: SP36-16
Keywords: Science & Technology
Life Sciences & Biomedicine
Primary Health Care
General & Internal Medicine
Cystatin C
Kidney failure
Diabetes
Thyroid
Cardiovascular
Cardiovascular
Cistatina C
Cystatin C
Diabetes
Insuficiencia renal
Kidney failure
Thyroid
Tiroides
Adolescent
Adult
Age Factors
Biomarkers
Child
Cross-Sectional Studies
Cystatin C
Diabetes Mellitus
Female
Heart Diseases
Humans
Male
Middle Aged
Prognosis
Sex Factors
Smoking
Thyroid Diseases
Young Adult
Humans
Heart Diseases
Diabetes Mellitus
Thyroid Diseases
Prognosis
Cross-Sectional Studies
Smoking
Age Factors
Sex Factors
Adolescent
Adult
Middle Aged
Child
Female
Male
Cystatin C
Young Adult
Biomarkers
Science & Technology
Life Sciences & Biomedicine
Primary Health Care
General & Internal Medicine
Cystatin C
Kidney failure
Diabetes
Thyroid
Cardiovascular
General & Internal Medicine
Publication Status: Published
Online Publication Date: 2018-11-30
Appears in Collections:Chemical Engineering



This item is licensed under a Creative Commons License Creative Commons