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Stereolithography printing of PCL-based bone graft substitutes

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Title: Stereolithography printing of PCL-based bone graft substitutes
Authors: Ovrebo, Oystein
Item Type: Thesis or dissertation
Abstract: Stereolithography printing stands out as a promising additive manufacturing technique for the production of bone graft substitutes and other tissue-engineered constructs due to a high spatial resolution, generation of internal microstructures, and high productivity. A current obstacle for the application of this manufacturing method is the limited library of biocompatible materials and non-standard characterization methods. In this work, a low molecular weight polycaprolactone (PCL) triacrylate resin was synthesized for stereolithography printing, characterized using ISO standard testing methods, and printed into complex lattice structures. The mechanical properties of the resin were characterized in tension (E = 12.2 MPa, σbreak = 1.49 MPa, εbreak = 13 %) and in compression (E = 97.99 MPa, σmax = 21.1 MPa, εmax = 30.1 %). Furthermore, the trade-off between scaffold stiffness and porosity was investigated for two cellular lattice structures (octet-truss and tetradecahedron) in silico using Finite Element Analysis (FEA). Initial FEA results indicate that the octet-truss lattice exhibits a higher stiffness at a lower relative density (ρ’ < 20 %) than the tetradecahedron lattice.
Content Version: Open Access
Issue Date: Dec-2020
Date Awarded: Mar-2021
URI: http://hdl.handle.net/10044/1/88447
DOI: https://doi.org/10.25560/88447
Copyright Statement: Creative Commons Attribution NonCommercial NoDerivatives Licence
Supervisor: Stevens, Molly
Jonathan, Jeffers
Sponsor/Funder: UK Research and Innovation
Cambridge Commonwealth, European & International Trust
Department: Materials
Publisher: Imperial College London
Qualification Level: Masters
Qualification Name: Master of Philosophy (MPhil)
Appears in Collections:Materials PhD theses



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