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Tissue texture extraction in indocyanine green fluorescence imaging for breast-conserving surgery

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Leiloglou_2021_J._Phys._D _Appl._Phys._54_194005.pdfPublished version3.32 MBAdobe PDFView/Open
Title: Tissue texture extraction in indocyanine green fluorescence imaging for breast-conserving surgery
Authors: Leiloglou, M
Chalau, V
Kedrzycki, MS
Thiruchelvam, P
Darzi, A
Leff, DR
Elson, DS
Item Type: Journal Article
Abstract: A two-camera fluorescence system for indocyanine green (ICG) signal detection has been developed and tested in a clinical feasibility trial of ten patients, with a resolution in the submillimetre scale. Immediately after systemic ICG injection, the two-camera system can detect ICG signals in vivo (~2.5 mg ${{\text{l}}^{ - 1}}$ or 3.2 × ${10^{ - 6}}{ }$ M). Qualitative assessment has shown that the fluorescence signal does not always correlate with the cancer location in the surgical scene. Conversely, fluorescence image texture metrics when used with the logistic regression model yields good accuracy scores in detecting cancer. We have demonstrated that intraoperative fluorescence imaging for resection guidance is a feasible solution to tackle the current challenge of positive resection margins in breast conserving surgery.
Issue Date: 13-May-2021
Date of Acceptance: 11-Feb-2021
URI: http://hdl.handle.net/10044/1/87895
DOI: 10.1088/1361-6463/abe571
ISSN: 0022-3727
Publisher: IOP Publishing
Journal / Book Title: Journal of Physics D: Applied Physics
Volume: 54
Issue: 19
Copyright Statement: © 2021 The Author(s). Published by IOP Publishing Ltd. Original content from this work may be used under the terms of the Creative Commons Attribution 4.0 license. Any further distribution of this work must maintain attribution to the author(s) and the title of the work, journal citation and DOI.
Sponsor/Funder: National Institute for Health Research
National Institute for Health Research
Imperial College Healthcare NHS Trust- BRC Funding
Imperial College Healthcare NHS Trust- BRC Funding
Medical Research Council (MRC)
Cancer Research UK
National Institute for Health Research
Cymtec Limited, Business & Technology Centre
Imperial College Healthcare NHS Trust- BRC Funding
AstraZeneca UK Limited
Funder's Grant Number: II-3A-1109-10038
RDB04 79560
PO 8300419389
Keywords: Science & Technology
Physical Sciences
Physics, Applied
fluorescence guided surgery (FGS)
breast-conserving surgery (BCS)
image texture metrics
indocyanine green
Applied Physics
02 Physical Sciences
09 Engineering
Publication Status: Published
Open Access location: https://iopscience.iop.org/article/10.1088/1361-6463/abe571/pdf
Article Number: ARTN 194005
Online Publication Date: 2021-02-25
Appears in Collections:Department of Surgery and Cancer
Institute of Global Health Innovation

This item is licensed under a Creative Commons License Creative Commons