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Plasma lectin pathway complement proteins in patients with COVID-19 and renal disease

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Title: Plasma lectin pathway complement proteins in patients with COVID-19 and renal disease
Authors: Medjeral-Thomas, N
Troldborg, A
Hansen, A
Gisby, J
Clarke, C
Prendecki, M
McAdoo, S
Sandhu, E
Lightstone, E
Thomas, D
Willicombe, M
Botto, M
Peters, J
Pickering, M
Thiel, S
Item Type: Journal Article
Abstract: We do not understand why non-white ethnicity and chronic kidney disease increase susceptibility to COVID-19. The lectin pathway of complement activation is a key contributor to innate immunity and inflammation. Concentrations of plasma lectin pathway proteins influence pathway activity and vary with ethnicity. We measured circulating lectin proteins in a multi-ethnic cohort of chronic kidney disease patients with and without COVID19 infection to determine if lectin pathway activation was contributing to COVID19 severity. We measured 11 lectin proteins in serial samples from a cohort of 33 patients with chronic kidney impairment and COVID19. Controls were single plasma samples from 32 patients on dialysis and 32 healthy individuals. We demonstrated multiple associations between recognition molecules and associated proteases of the lectin pathway and COVID-19, including COVID-19 severity. Some of these associations were unique to patients of Asian and White ethnicity. Our novel findings demonstrate that COVID19 infection alters the concentration of plasma lectin proteins and some of these changes were linked to ethnicity. This suggests a role for the lectin pathway in the host response to COVID-19 and suggest that variability within this pathway may contribute to ethnicity-associated differences in susceptibility to severe COVID-19.
Issue Date: 29-Apr-2021
Date of Acceptance: 12-Apr-2021
URI: http://hdl.handle.net/10044/1/87893
DOI: 10.3389/fimmu.2021.671052
ISSN: 1664-3224
Publisher: Frontiers Media
Journal / Book Title: Frontiers in Immunology
Volume: 12
Copyright Statement: © 2021 Medjeral-Thomas, Troldborg, Hansen, Gisby, Clarke, Prendecki, McAdoo, Sandhu, Lightstone, Thomas, Willicombe, Botto, Peters, Pickering and Thiel. This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) and the copyright owner(s) are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms.
Sponsor/Funder: NIHR Health Services and Delivery Research (HS&DR) programme
United Kingdom Research and Innovation
Wellcome Trust
Medical Research Council (MRC)
UK Research and Innovation
Wellcome Trust
Funder's Grant Number: MR/S004068/1
097816/Z/11/ZR
MR/V027638/1
1257927
212252/Z/18/Z
Keywords: 1107 Immunology
1108 Medical Microbiology
Publication Status: Published
Article Number: ARTN 671052
Appears in Collections:Department of Immunology and Inflammation
Faculty of Medicine



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