Atrial fibrillation and obesity: long-term incidence and outcomes after bariatric surgery

Title: Atrial fibrillation and obesity: long-term incidence and outcomes after bariatric surgery
Authors: Ardissino, M
Moussa, O
Eichhorn, C
Reddy, R
Khan, O
Ziprin, P
Darzi, A
Collins, P
Purkayastha, S
Item Type: Conference Paper
Abstract: Background Obesity is among the fastest growing global health threats. Among the management options for patients with obesity, bariatric surgery is a rapidly evolving field that has been shown to result in reliable weight loss. The association between obesity and atrial fibrillation has been well established; but the long-term impact of bariatric surgery on atrial fibrillation has not yet been explored. This study aims to assess the long-term incidence and resolution rates of atrial fibrillation in patients who undergo bariatric surgery in the United Kingdom. Methods The primary and secondary electronic healthcare records included in the Clinical Practice Research Datalink (CPRD) database were used to conduct a nation-wide cohort study. The 3,077 patients in the CPRD with no previous history of atrial fibrillation who had undergone bariatric surgery, were matched to 3,077 age, gender and BMI matched controls, also with no past history of atrial fibrillation. The primary endpoint was the incidence of any type of atrial fibrillation by clinical coded diagnosis. The secondary endpoint was a coded resolution of atrial fibrillation among the patients who received a diagnosis during follow-up. Results Patients were followed up for a median of 12.3 years; the median age was 50 years and median BMI was 43 kg/m2. Patients who had undergone bariatric surgery did not have a significantly lower occurrence of the primary outcome of incident AF (adjusted HR 0.720; 95% CI 0.492–1.054; p=0.091). However, secondary analysis among patients with AF identified higher rates of resolution among patients who had undergone bariatric surgery (p=0.049). Conclusion The results of this nationwide cohort study identify an association between bariatric surgery and higher rates of AF resolution; and describe a non-significant but biologically plausible trend towards lower rates of incident AF in patients who underwent bariatric surgery.
Issue Date: 24-Mar-2020
Date of Acceptance: 1-Mar-2020
URI: http://hdl.handle.net/10044/1/87688
ISSN: 0735-1097
Publisher: ELSEVIER SCIENCE INC
Start Page: 1986
End Page: 1986
Journal / Book Title: JOURNAL OF THE AMERICAN COLLEGE OF CARDIOLOGY
Volume: 75
Issue: 11
Sponsor/Funder: Imperial College Healthcare NHS Trust
National Institute of Health Research
Funder's Grant Number: 72100-74250
Conference Name: Conference of American-College-of-Cardiology (ACC) / World Congress of Cardiology (WCC)
Keywords: Science & Technology
Life Sciences & Biomedicine
Cardiac & Cardiovascular Systems
Cardiovascular System & Cardiology
Science & Technology
Life Sciences & Biomedicine
Cardiac & Cardiovascular Systems
Cardiovascular System & Cardiology
Cardiovascular System & Hematology
1102 Cardiorespiratory Medicine and Haematology
1117 Public Health and Health Services
Publication Status: Published
Start Date: 2020-03-28
Finish Date: 2020-03-30
Conference Place: Chicago, IL
Open Access location: https://www.jacc.org/doi/10.1016/S0735-1097%2820%2932613-9
Online Publication Date: 2020-03-29
Appears in Collections:Department of Surgery and Cancer
Institute of Global Health Innovation



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