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Conservative route to genome compaction in a miniature annelid

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Title: Conservative route to genome compaction in a miniature annelid
Authors: Martin-Duran, JM
Vellutini, BC
Marletaz, F
Cetrangolo, V
Cvetesic, N
Thiel, D
Henriet, S
Grau-Bove, X
Carrillo-Baltodano, AM
Gu, W
Kerbl, A
Marquez, Y
Bekkouche, N
Chourrout, D
Gomez-Skarmeta, JL
Irimia, M
Lenhard, B
Worsaae, K
Hejnol, A
Item Type: Journal Article
Abstract: The causes and consequences of genome reduction in animals are unclear because our understanding of this process mostly relies on lineages with often exceptionally high rates of evolution. Here, we decode the compact 73.8-megabase genome of Dimorphilus gyrociliatus, a meiobenthic segmented worm. The D. gyrociliatus genome retains traits classically associated with larger and slower-evolving genomes, such as an ordered, intact Hox cluster, a generally conserved developmental toolkit and traces of ancestral bilaterian linkage. Unlike some other animals with small genomes, the analysis of the D. gyrociliatus epigenome revealed canonical features of genome regulation, excluding the presence of operons and trans-splicing. Instead, the gene-dense D. gyrociliatus genome presents a divergent Myc pathway, a key physiological regulator of growth, proliferation and genome stability in animals. Altogether, our results uncover a conservative route to genome compaction in annelids, reminiscent of that observed in the vertebrate Takifugu rubripes.
Issue Date: 16-Nov-2020
Date of Acceptance: 15-Sep-2020
URI: http://hdl.handle.net/10044/1/87376
DOI: 10.1038/s41559-020-01327-6
ISSN: 2397-334X
Publisher: Nature Research
Start Page: 231
End Page: 242
Journal / Book Title: Nature Ecology and Evolution
Volume: 5
Issue: 2
Copyright Statement: © The Author(s) 2020. This article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adap tation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons license, and indicate if changes were made. The images or other third party material in this article are included in the article’s Creative Commons license, unless indicated otherwise in a credit line to the material. If material is not included in the article’s Creative Commons license and your intended use is not permitted by statu tory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this license, visit http://creativecommons.org/licenses/by/4.0/.
Sponsor/Funder: Wellcome Trust
Funder's Grant Number: 106954/Z/15/Z
Keywords: Science & Technology
Life Sciences & Biomedicine
Ecology
Evolutionary Biology
Environmental Sciences & Ecology
TRANSCRIPTIONAL CONTROL
NERVOUS-SYSTEM
DNA CONTENT
BODY-SIZE
CELL-SIZE
EVOLUTION
SEQUENCE
ALIGNMENT
REVEALS
GENES
Animals
Annelida
Evolution, Molecular
Genetic Linkage
Genome
Takifugu
Animals
Takifugu
Annelida
Evolution, Molecular
Genome
Genetic Linkage
Science & Technology
Life Sciences & Biomedicine
Ecology
Evolutionary Biology
Environmental Sciences & Ecology
TRANSCRIPTIONAL CONTROL
NERVOUS-SYSTEM
DNA CONTENT
BODY-SIZE
CELL-SIZE
EVOLUTION
SEQUENCE
ALIGNMENT
REVEALS
GENES
Publication Status: Published
Open Access location: https://www.nature.com/articles/s41559-020-01327-6
Online Publication Date: 2020-11-16
Appears in Collections:Institute of Clinical Sciences



This item is licensed under a Creative Commons License Creative Commons