Succession of bifidobacterium longum strains in response to a changing early life nutritional environment reveals dietary substrate adaptations

Title: Succession of bifidobacterium longum strains in response to a changing early life nutritional environment reveals dietary substrate adaptations
Authors: Kujawska, M
La Rosa, SL
Roger, LC
Pope, PB
Hoyles, L
McCartney, AL
Hall, LJ
Item Type: Journal Article
Abstract: Diet-microbe interactions play a crucial role in modulation of the early life microbiota and infant health. Bifidobacterium dominates the breast-fed infant gut and may persist in individuals during transition from a milk-based to a more diversified diet. Here, we investigated adaptation of Bifidobacterium longum to the changing nutritional environment. Genomic characterization of 75 strains isolated from nine either exclusively breast- or formula-fed (pre-weaning) infants in their first 18 months revealed subspecies- and strain-specific intra-individual genomic diversity with respect to carbohydrate metabolism, which corresponded to different dietary stages. Complementary phenotypic studies indicated strain-specific differences in utilization of human milk oligosaccharides and plant carbohydrates, whereas proteomic profiling identified gene clusters involved in metabolism of selected carbohydrates. Our results indicate a strong link between infant diet and B. longum diversity and provide additional insights into possible competitive advantage mechanisms of this Bifidobacterium species and its persistence in a single host.
Issue Date: 21-Aug-2020
Date of Acceptance: 13-Jul-2020
URI: http://hdl.handle.net/10044/1/87327
DOI: 10.1016/j.isci.2020.101368
ISSN: 2589-0042
Publisher: Cell Press
Start Page: 1
End Page: 29
Journal / Book Title: iScience
Volume: 23
Issue: 8
Copyright Statement: © 2020 The Authors. This is an open access article under the CC BY license (http://creativecommons.org/licenses/by/4.0/).
Sponsor/Funder: Medical Research Council (MRC)
Medical Research Council (MRC)
Funder's Grant Number: MR/L01632X/1
MR/L01632X/1
Keywords: Science & Technology
Multidisciplinary Sciences
Science & Technology - Other Topics
MILK OLIGOSACCHARIDE CONSUMPTION
FECAL MICROBIOTA
GUT MICROBIOME
FED INFANTS
SUBSP-NOV.
HEALTH
IDENTIFICATION
TRANSMISSION
METABOLISM
EVOLUTION
Dietary Supplement
Microbiology
Microbiome
Science & Technology
Multidisciplinary Sciences
Science & Technology - Other Topics
MILK OLIGOSACCHARIDE CONSUMPTION
FECAL MICROBIOTA
GUT MICROBIOME
FED INFANTS
SUBSP-NOV.
HEALTH
IDENTIFICATION
TRANSMISSION
METABOLISM
EVOLUTION
Publication Status: Published
Article Number: ARTN 101368
Online Publication Date: 2020-07-15
Appears in Collections:Department of Surgery and Cancer



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