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Bacteriophages of Klebsiella spp., their diversity and potential therapeutic uses

Title: Bacteriophages of Klebsiella spp., their diversity and potential therapeutic uses
Authors: Herridge, WP
Shibu, P
O'Shea, J
Brook, TC
Hoyles, L
Item Type: Journal Article
Abstract: Klebsiella spp. are commensals of the human microbiota, and a leading cause of opportunistic nosocomial infections. The incidence of multidrug resistant (MDR) strains of Klebsiella pneumoniae causing serious infections is increasing, and Klebsiella oxytoca is an emerging pathogen. Alternative strategies to tackle infections caused by these bacteria are required as strains become resistant to last-resort antibiotics such as colistin. Bacteriophages (phages) are viruses that can infect and kill bacteria. They and their gene products are now being considered as alternatives or adjuncts to antimicrobial therapies. Several in vitro and in vivo studies have shown the potential for lytic phages to combat MDR K. pneumoniae infections. Ready access to cheap sequencing technologies has led to a large increase in the number of genomes available for Klebsiella -infecting phages, with these phages being heterogeneous at the whole-genome level. This review summarizes our current knowledge on phages of Klebsiella spp. and highlights technological and biological issues relevant to the development of phage-based therapies targeting these bacteria.
Issue Date: 1-Jan-2020
Date of Acceptance: 20-Dec-2019
URI: http://hdl.handle.net/10044/1/87326
DOI: 10.1099/jmm.0.001141
ISSN: 0022-2615
Publisher: Microbiology Society
Start Page: 176
End Page: 194
Journal / Book Title: Journal of Medical Microbiology
Volume: 69
Issue: 2
Copyright Statement: © 2020 The Authors This is an open-access article distributed under the terms of the Creative Commons Attribution NonCommercial License. This article was made open access via a Publish and Read agreement between the Microbiology Society and the corresponding author’s institution.
Sponsor/Funder: Medical Research Council (MRC)
Medical Research Council (MRC)
Funder's Grant Number: MR/L01632X/1
MR/L01632X/1
Keywords: Science & Technology
Life Sciences & Biomedicine
Microbiology
antimicrobial resistance
phage therapy
Klebsiella oxytoca
Klebsiella pneumoniae
BURN WOUND-INFECTION
COMPLETE GENOME SEQUENCE
RISK-FACTORS
ESCHERICHIA-COLI
CAPSULAR POLYSACCHARIDE
POPULATION-STRUCTURE
PNEUMONIAE B5055
HOST-RANGE
RESISTANT
PHAGE
Klebsiella oxytoca
Klebsiella pneumoniae
antimicrobial resistance
phage therapy
Animals
Bacteriophages
Biodiversity
Humans
Klebsiella
Klebsiella Infections
Phage Therapy
Animals
Humans
Klebsiella
Bacteriophages
Klebsiella Infections
Biodiversity
Phage Therapy
Science & Technology
Life Sciences & Biomedicine
Microbiology
antimicrobial resistance
phage therapy
Klebsiella oxytoca
Klebsiella pneumoniae
BURN WOUND-INFECTION
COMPLETE GENOME SEQUENCE
RISK-FACTORS
ESCHERICHIA-COLI
CAPSULAR POLYSACCHARIDE
POPULATION-STRUCTURE
PNEUMONIAE B5055
HOST-RANGE
RESISTANT
PHAGE
Microbiology
06 Biological Sciences
07 Agricultural and Veterinary Sciences
11 Medical and Health Sciences
Publication Status: Published
Online Publication Date: 2020-01-24
Appears in Collections:Department of Surgery and Cancer



This item is licensed under a Creative Commons License Creative Commons