2
IRUS Total
Downloads

Replacement of red and processed meat with other food sources of protein and the risk of type 2 diabetes in European populations: The EPIC-interAct study

File Description SizeFormat 
EPIC-InterAct_replace_redmeat_alternatives_accepted.docxAccepted version113.93 kBMicrosoft WordView/Open
Title: Replacement of red and processed meat with other food sources of protein and the risk of type 2 diabetes in European populations: The EPIC-interAct study
Authors: Ibsen, DB
Steur, M
Imamura, F
Overvad, K
Schulze, MB
Bendinelli, B
Guevara, M
Agudo, A
Amiano, P
Aune, D
Barricarte, A
Ericson, U
Fagherazzi, G
Franks, PW
Freisling, H
Quiros, JR
Grioni, S
Heath, AK
Huybrechts, I
Katze, V
Laouali, N
Mancini, F
Masala, G
Olsen, A
Papier, K
Ramne, S
Rolandsson, O
Sacerdote, C
Sanchez, M-J
Santiuste, C
Simeon, V
Spijkerman, AMW
Srour, B
Tjonneland, A
Tong, TYN
Tumino, R
Van der Schouw, YT
Weiderpass, E
Wittenbecher, C
Sharp, SJ
Riboli, E
Forouhi, NG
Wareham, NJ
Item Type: Journal Article
Abstract: OBJECTIVE There is sparse evidence for the association of suitable food substitutions for red and processed meat on the risk of type 2 diabetes. We modeled the association between replacing red and processed meat with other protein sources and the risk of type 2 diabetes and estimated its population impact. RESEARCH DESIGN AND METHODS The European Prospective Investigation into Cancer (EPIC)-InterAct case cohort included 11,741 individuals with type 2 diabetes and a subcohort of 15,450 participants in eight countries. We modeled the replacement of self-reported red and processed meat with poultry, fish, eggs, legumes, cheese, cereals, yogurt, milk, and nuts. Country-specific hazard ratios (HRs) for incident type 2 diabetes were estimated by Prentice-weighted Cox regression and pooled using random-effects meta-analysis. RESULTS There was a lower hazard for type 2 diabetes for the modeled replacement of red and processed meat (50 g/day) with cheese (HR 0.90, 95% CI 0.83–0.97) (30 g/day), yogurt (0.90, 0.86–0.95) (70 g/day), nuts (0.90, 0.84–0.96) (10 g/day), or cereals (0.92, 0.88–0.96) (30 g/day) but not for replacements with poultry, fish, eggs, legumes, or milk. If a causal association is assumed, replacing red and processed meat with cheese, yogurt, or nuts could prevent 8.8%, 8.3%, or 7.5%, respectively, of new cases of type 2 diabetes. CONCLUSIONS Replacement of red and processed meat with cheese, yogurt, nuts, or cereals was associated with a lower rate of type 2 diabetes. Substituting red and processed meat by other protein sources may contribute to the prevention of incident type 2 diabetes in European populations.
Issue Date: 1-Nov-2020
Date of Acceptance: 24-Jul-2020
URI: http://hdl.handle.net/10044/1/87277
DOI: 10.2337/dc20-1038
ISSN: 0149-5992
Publisher: American Diabetes Association
Start Page: 2660
End Page: 2667
Journal / Book Title: Diabetes Care
Volume: 43
Issue: 11
Copyright Statement: © 2020 by the American Diabetes Association https://www.diabetesjournals.org/content/licenseReaders may use this article as long as the work is properly cited, the use is educational and not for profit, and the work is not altered. More information is available at https://www.diabetesjournals.org/content/license.
Sponsor/Funder: World Cancer Research Fund International
Commission of the European Communities
Funder's Grant Number: 2009/44
313010
Keywords: Science & Technology
Life Sciences & Biomedicine
Endocrinology & Metabolism
CONSUMPTION
ASSOCIATION
CANCER
MELLITUS
IRON
METAANALYSIS
COUNTRIES
FERRITIN
VALIDITY
MEN
Science & Technology
Life Sciences & Biomedicine
Endocrinology & Metabolism
CONSUMPTION
ASSOCIATION
CANCER
MELLITUS
IRON
METAANALYSIS
COUNTRIES
FERRITIN
VALIDITY
MEN
Endocrinology & Metabolism
11 Medical and Health Sciences
Publication Status: Published
Open Access location: https://care.diabetesjournals.org/content/43/11/2660.long
Online Publication Date: 2020-10-20
Appears in Collections:School of Public Health