Tuning the gelation of thermoresponsive gels based on triblock terpolymers

Title: Tuning the gelation of thermoresponsive gels based on triblock terpolymers
Authors: Constantinou, AP
Zhan, B
Georgiou, TK
Item Type: Journal Article
Abstract: In need of new thermoresponsive gels, a novel combination of repeated units is reported in this study, with the best-performing polymer outperforming the commercial counterpart pluronic F127 by gelling at body temperatures at concentrations as low as 3 w/w%. These polymers are ABC triblock terpolymers of constant molar mass (MM), where A, B, and C blocks consist of hydrophilic oligo(ethylene glycol) methyl ether methacrylate with an average molar mass of 300 g mol–1 (OEGMA300), hydrophobic n-butyl methacrylate (BuMA), and the thermoresponsive di(ethylene glycol) methyl ether methacrylate (DEGMA), respectively. In total, 15 triblock terpolymers were synthesized via group transfer polymerization (GTP), and their composition was systematically varied. Key focus was the characterization of their gelation properties via visual tests and rheological measurements. It was concluded that achieving the optimum hydrophilicity/hydrophobicity ratio is critical to ensure a clear solution to gel transition and a wide gelation area that includes the body temperature.
Issue Date: 5-Feb-2021
Date of Acceptance: 26-Jan-2021
DOI: 10.1021/acs.macromol.0c02533
ISSN: 0024-9297
Publisher: American Chemical Society (ACS)
Start Page: 1943
End Page: 1960
Journal / Book Title: Macromolecules
Volume: 54
Issue: 4
Copyright Statement: © 2021 American Chemical Society. This document is the Accepted Manuscript version of a Published Work that appeared in final form in Macromolecules, after peer review and technical editing by the publisher. To access the final edited and published work see
Sponsor/Funder: Engineering & Physical Science Research Council (E
Engineering and Physical Sciences Research Council
Funder's Grant Number: MMRE_P75852
Keywords: Polymers
03 Chemical Sciences
09 Engineering
Publication Status: Published
Article Number: acs.macromol.0c02533
Online Publication Date: 2021-02-05
Appears in Collections:Materials
Faculty of Engineering