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Metabolomics - the stethoscope for the 21st century

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Title: Metabolomics - the stethoscope for the 21st century
Authors: Ashrafian, H
Sounderajah, V
Glen, R
Ebbels, T
Blaise, BJ
Kalra, D
Kultima, K
Spjuth, O
Tenori, L
Salek, R
Kale, N
Haug, K
Schober, D
Rocca-Serra, P
O'Donovan, C
Steinbeck, C
Cano, I
De Atauri, P
Cascante, M
Item Type: Journal Article
Abstract: Metabolomics offers systematic identification and quantification of all metabolic products from the human body. This field could provide clinicians with new sets of diagnostic biomarkers for disease states in addition to quantifying treatment response to medications at an individualised level. This literature review aims to highlight the technology underpinning metabolic profiling, identify potential applications of metabolomics in clinical practice and discuss the translational challenges that the field faces. We searched PubMed, Medline and Embase for primary and secondary research articles regarding clinical applications of metabolomics. Metabolic profiling can be performed using mass spectrometry and NMR based techniques using a variety of biological samples. This is carried out in vivo or in vitro following careful sample collection, preparation and analysis. The potential clinical applications constitute disruptive innovations in their respective specialities, particularly oncology and metabolic medicine. Outstanding issues currently preventing widespread clinical use centre around scalability of data interpretation, standardisation of sample handling practice and e-infrastructure. Routine utilisation of metabolomics at a patient and population level will constitute an integral part of future healthcare provision.
Issue Date: 3-Dec-2020
Date of Acceptance: 29-Nov-2020
URI: http://hdl.handle.net/10044/1/86807
DOI: 10.1159/000513545
ISSN: 1011-7571
Publisher: Karger
Start Page: 301
End Page: 310
Journal / Book Title: Medical Principles and Practice
Volume: 30
Issue: 4
Copyright Statement: © 2020 The Author(s) Published by S. Karger AG, Basel karger@karger.com www.karger.com/mpp Significance of the Study • Metabolomics encompasses the systematic identification and quantification of all metabolic products from the human body. • This field could provide clinicians with novel sets of diagnostic biomarkers for disease states, in addition to quantifying treatment response to medications at an individualized level. • Outstanding issues preventing widespread clinical use are scalability of data interpretation, standardization of sample handling practice, and e-infrastructure. DOI: 10.1159/000513545 Keywords Metabolomics · Personalised medicine · Precision medicine Abstract Metabolomics encompasses the systematic identification and quantification of all metabolic products in the human body. This field could provide clinicians with novel sets of diagnostic biomarkers for disease states in addition to quantifying treatment response to medications at an individualized level. This literature review aims to highlight the technology underpinning metabolic profiling, identify potential applications of metabolomics in clinical practice, and discuss the translational challenges that the field faces. We searched PubMed, MEDLINE, and EMBASE for primary and secondary research articles regarding clinical applications of metaboloThis is an Open Access article licensed under the Creative Commons Attribution-NonCommercial-4.0 International License (CC BY-NC) (http://www.karger.com/Services/OpenAccessLicense), applicable to the online version of the article only. Usage and distribution for commercial purposes requires written permission.
Sponsor/Funder: National Institute of Health Research
Keywords: Metabolomics
Personalised medicine
Precision medicine
Microbiology
1117 Public Health and Health Services
Publication Status: Published
Conference Place: Switzerland
Online Publication Date: 2020-12-03
Appears in Collections:Department of Metabolism, Digestion and Reproduction
Department of Surgery and Cancer
Faculty of Medicine
Institute of Global Health Innovation



This item is licensed under a Creative Commons License Creative Commons