13
IRUS Total
Downloads
  Altmetric

T-Bet controls cellularity of intestinal group 3 innate lymphoid cells

File Description SizeFormat 
fimmu-11-623324.pdfPublished version2.58 MBAdobe PDFView/Open
Title: T-Bet controls cellularity of intestinal group 3 innate lymphoid cells
Authors: Schroeder, J-H
Meissl, K
Hromadova, D
Lo, JW
Neves, JF
Howard, JK
Helmby, H
Powell, N
Strobl, B
Lord, GM
Item Type: Journal Article
Abstract: Innate lymphoid cells (ILC) play a significant immunological role at mucosal surfaces such as the intestine. T-bet-expressing group 1 innate lymphoid cells (ILC1) are believed to play a substantial role in inflammatory bowel disease (IBD). However, a role of T-bet-negative ILC3 in driving colitis has also been suggested in mouse models questioning T-bet as a critical factor for IBD. We report here that T-bet deficient mice had a greater cellularity of NKp46-negative ILC3 correlating with enhanced expression of RORγt and IL-7R, but independent of signaling through STAT1 or STAT4. We observed enhanced neutrophilia in the colonic lamina propria (cLP) of these animals, however, we did not detect a greater risk of T-bet-deficient mice to develop spontaneous colitis. Furthermore, by utilizing an in vivo fate-mapping approach, we identified a population of T-bet-positive precursors in NKp46-negative ILC3s. These data suggest that T-bet controls ILC3 cellularity, but does do not drive a pathogenic role of ILC3 in mice with a conventional specific pathogen-free microbiota.
Issue Date: 2-Feb-2021
Date of Acceptance: 15-Dec-2020
URI: http://hdl.handle.net/10044/1/86797
DOI: 10.3389/fimmu.2020.623324
ISSN: 1664-3224
Publisher: Frontiers Media
Start Page: 1
End Page: 11
Journal / Book Title: Frontiers in Immunology
Volume: 11
Copyright Statement: © 2021 Schroeder, Meissl, Hromadová, Lo, Neves, Howard, Helmby, Powell, Strobl and Lord. This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) and the copyright owner(s) are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms.
Keywords: Science & Technology
Life Sciences & Biomedicine
Immunology
T-bet
innate lymphoid cells
ILCs
intestinal inflammation
mucosal homeostasis
ILCs
T-bet
innate lymphoid cells
intestinal inflammation
mucosal homeostasis
Science & Technology
Life Sciences & Biomedicine
Immunology
T-bet
innate lymphoid cells
ILCs
intestinal inflammation
mucosal homeostasis
1107 Immunology
1108 Medical Microbiology
Publication Status: Published
Open Access location: https://doi.org/10.3389/fimmu.2020.623324
Article Number: ARTN 623324
Online Publication Date: 2021-02-02
Appears in Collections:Department of Metabolism, Digestion and Reproduction



This item is licensed under a Creative Commons License Creative Commons