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Long non-coding RNAs as key modulators of pancreatic β-Cell mass and function

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Title: Long non-coding RNAs as key modulators of pancreatic β-Cell mass and function
Authors: López-Noriega, L
Rutter, GA
Item Type: Journal Article
Abstract: Numerous studies have sought to decipher the genetic and other mechanisms contributing to β-cell loss and dysfunction in diabetes mellitus. However, we have yet to fully understand the etiology of the disease or to develop satisfactory treatments. Since the majority of diabetes susceptibility loci are mapped to non-coding regions within the genome, understanding the functions of non-coding RNAs in β-cell biology might provide crucial insights into the pathogenesis of type 1 (T1D) and type 2 (T2D) diabetes. During the past decade, numerous studies have indicated that long non-coding RNAs play important roles in the maintenance of β-cell mass and function. Indeed, lncRNAs have been shown to be involved in controlling β-cell proliferation during development and/or β-cell compensation in response to hyperglycaemia. LncRNAs such as TUG-1 and MEG3 play a role in both β-cell apoptosis and function, while others sensitize β-cells to apoptosis in response to stress signals. In addition, several long non-coding RNAs have been shown to regulate the expression of β-cell-enriched transcription factors in cis or in trans. In this review, we provide an overview of the roles of lncRNAs in maintaining β-function and mass, and discuss their relevance in the development of diabetes.
Issue Date: 8-Feb-2021
Date of Acceptance: 21-Dec-2020
URI: http://hdl.handle.net/10044/1/86640
DOI: 10.3389/fendo.2020.610213
ISSN: 1664-2392
Publisher: Frontiers Media
Journal / Book Title: Frontiers in Endocrinology
Volume: 11
Copyright Statement: © 2021 López–Noriega and Rutter. This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) and the copyright owner(s) are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms.
Sponsor/Funder: Diabetes UK
Wellcome Trust
MRC Programme Grant
Funder's Grant Number: 15 / 0005275
212625/Z/18/Z
MR/R022259/1
Keywords: beta cell
diabetes
insulin
islet
lncRNA
beta cell
diabetes
insulin
islet
lncRNA
1103 Clinical Sciences
1111 Nutrition and Dietetics
Publication Status: Published
Conference Place: Switzerland
Article Number: ARTN 610213
Appears in Collections:Department of Metabolism, Digestion and Reproduction



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