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A pH/redox-dual responsive, nanoemulsion-embedded hydrogel for efficient oral delivery and controlled intestinal release of magnesium ions

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Title: A pH/redox-dual responsive, nanoemulsion-embedded hydrogel for efficient oral delivery and controlled intestinal release of magnesium ions
Authors: Huang, Y
Wang, Z
Zhang, G
Ren, J
Yu, L
Liu, X
Yang, Y
Ravindran, A
Wong, C
Chen, R
Item Type: Journal Article
Abstract: It remains a major challenge to achieve efficient oral delivery and controlled intestinal release of ions using hydrogels. Herein, we report a novel, pH/redox-dual responsive, nanoemulsion-embedded composite hydrogel to address this issue. The hydrogel was first synthesized by crosslinking a biocompatible, pH-responsive pseudopeptide, poly(L-lysine isophthalamide) (PLP), and redox-sensitive L-cystine dimethyl ester dihydrochloride (CDE). A suitable amount of magnesium acetate was encapsulated into oil-in-water nanoemulsions, which were then embedded into the lysine-based hydrogel. The resulting composite hydrogel collapsed into a compact structure at acidic gastric pH, but became highly swollen or degraded in the neutral and reducing intestinal environment. The ion release profiles indicated that the nanoemulsion-embedded composite hydrogel could well retain and protect magnesium ions in the simulated gastric fluid (SGF) buffer at pH 1.2, but efficiently release them in the simulated intestinal fluid (SIF) buffer at pH 6.8 in the presence of 1,4-dithiothreitol (DTT) as a reducing agent. Moreover, this composite hydrogel system displayed good biocompatibility. These results suggested that the pH/redox-dual responsive, nanoemulsion-embedded composite hydrogel could be a promising candidate for efficient oral delivery and controlled intestinal release of magnesium and other ions.
Issue Date: 28-Jan-2021
Date of Acceptance: 26-Jan-2021
URI: http://hdl.handle.net/10044/1/86607
DOI: 10.1039/d0tb02442b
ISSN: 2050-750X
Publisher: Royal Society of Chemistry (RSC)
Start Page: 1888
End Page: 1895
Journal / Book Title: Journal of Materials Chemistry B
Volume: 9
Issue: 7
Copyright Statement: © The Royal Society of Chemistry 2021. This article is licensed under a Creative Commons Attribution 3.0 Unported Licence.
Sponsor/Funder: Engineering & Physical Science Research Council (EPSRC)
Funder's Grant Number: EP/R013764/1
Keywords: 0303 Macromolecular and Materials Chemistry
0903 Biomedical Engineering
Publication Status: Published
Online Publication Date: 2021-01-28
Appears in Collections:Chemical Engineering
Faculty of Engineering



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