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Obesity and polycystic ovary syndrome

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Title: Obesity and polycystic ovary syndrome
Authors: Barber, TM
Franks, S
Item Type: Journal Article
Abstract: The increased global prevalence of obesity over the last 40‐years has driven a rise in prevalence of obesity‐related co‐morbidities, including polycystic ovary syndrome (PCOS). On a background of genetic susceptibility, PCOS often becomes clinically manifest following weight gain, commonly during adolescence. A common endocrinopathy affecting between 6%‐10% of reproductive‐age women, PCOS presents with the cardinal features of hyperandrogenism, reproductive and metabolic dysfunction. PCOS associates with insulin resistance, independently of (but amplified by) obesity. Insulin resistance in PCOS is characterized by abnormal post‐receptor signalling within the phosphatidylinositol‐kinase (PI3‐K) pathway. Multiple factors (including most notably, weight gain) contribute towards the severity of insulin resistance in PCOS. Compensatory hyperinsulinaemia ensues, resulting in over‐stimulation of the (intact) post‐receptor mitogen‐activated protein kinase (MAP‐K) insulin pathway, with consequent implications for steroidogenesis and ovarian function. In this concise review, we explore the effects of weight gain and obesity on the pathogenesis of PCOS from the perspective of its three cardinal features of hyperandrogenism, reproductive and metabolic dysfunction, with a focus on the central mediating role of the insulin pathway. We also consider key lifestyle strategies for the effective management of obese and overweight women with PCOS.
Issue Date: Oct-2021
Date of Acceptance: 14-Jan-2021
URI: http://hdl.handle.net/10044/1/86545
DOI: 10.1111/cen.14421
ISSN: 0300-0664
Publisher: Society for Endocrinology
Start Page: 531
End Page: 541
Journal / Book Title: Clinical Endocrinology
Volume: 95
Issue: 4
Copyright Statement: © 2021 The Authors. Clinical Endocrinology published by John Wiley & Sons Ltd. This is an open access article under the terms of the Creative Commons Attribution‐NonCommercial‐NoDerivs License, which permits use and distribution in any medium, provided the original work is properly cited, the use is non‐commercial and no modifications or adaptations are made.
Keywords: Science & Technology
Life Sciences & Biomedicine
Endocrinology & Metabolism
metabolism
obesity
polycystic ovary syndrome
OBSTRUCTIVE SLEEP-APNEA
HORMONE-BINDING GLOBULIN
FOLLICLE-STIMULATING-HORMONE
EXERCISE TRAINING-PROGRAM
INSULIN-RESISTANCE
LUTEINIZING-HORMONE
ANOVULATORY WOMEN
VISCERAL FAT
5-ALPHA-REDUCTASE ACTIVITY
CARDIOVASCULAR-DISEASE
metabolism
obesity
polycystic ovary syndrome
Science & Technology
Life Sciences & Biomedicine
Endocrinology & Metabolism
metabolism
obesity
polycystic ovary syndrome
Endocrinology & Metabolism
1103 Clinical Sciences
1114 Paediatrics and Reproductive Medicine
Publication Status: Published
Online Publication Date: 2021-01-18
Appears in Collections:Department of Metabolism, Digestion and Reproduction
Faculty of Medicine



This item is licensed under a Creative Commons License Creative Commons